W1895
WAY-100135
≥98% (HPLC)
别名:
3-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-phenyl-N-tert-butyl-propanamide dihydrochloride;, N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl) -2-phenylpropanamide dihydrochloride
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关于此项目
经验公式（希尔记法）:
C24H33N3O2 · 2HCl
化学文摘社编号:
分子量:
468.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
H2O: ≥10 mg/mL
originator
Wyeth
storage temp.
2-8°C
SMILES string
Cl.Cl.COc1ccccc1N2CCN(CC2)CC(C(=O)NC(C)(C)C)c3ccccc3
InChI
1S/C24H33N3O2.2ClH/c1-24(2,3)25-23(28)20(19-10-6-5-7-11-19)18-26-14-16-27(17-15-26)21-12-8-9-13-22(21)29-4;;/h5-13,20H,14-18H2,1-4H3,(H,25,28);2*1H
InChI key
VJGZNBYDSDEOED-UHFFFAOYSA-N
Biochem/physiol Actions
WAY-100135 is a potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). It is selective over 5-HT1B, 1C, 2,α1, α2 and D2 receptors (IC50 > 1000 nM).
WAY-100135 is a potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Selective over 5-HT1B,1C,2, α1, α2 and D2 receptors (IC50 > 1000 nM).
Features and Benefits
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
We offer many products related to serotonin receptors for your research needs.
我们提供许多血清素受体相关产品，满足您的各类研究需求。
Kangjian Xiang et al.
Current neurovascular research, 13(4), 321-328 (2016-10-26)
Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that modulates N-methyl-D-aspartate (NMDA) receptor activity by binding to several different 5-HT receptor subtypes. In the present study, we used whole-cell patch-clamp recordings in transverse slice preparations to test the role of 5-HT
Daniel Sobrido-Cameán et al.
Disease models & mechanisms, 12(2) (2019-02-03)
Classical neurotransmitters are mainly known for their roles as neuromodulators, but they also play important roles in the control of developmental and regenerative processes. Here, we used the lamprey model of spinal cord injury to study the effect of serotonin
Lei Han et al.
The Journal of physiology, 599(1), 253-267 (2020-10-03)
Chemogenetic activation of medial vestibular nucleus-projecting 5-HT neurons resulted in deficits in vestibular-mediated tasks, including negative geotaxis, balance beam and rota-rod tests. The 5-HT1A receptor mediates the vestibular-related behavioural effects of 5-HT in the vestibular nucleus. 5-HT1A receptor activation attenuated
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| W1895-5MG | 04061832078304 |
| W1895-25MG | 04061837488740 |