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Merck
CN

W1895

WAY-100135

≥98% (HPLC)

别名:

3-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-phenyl-N-tert-butyl-propanamide dihydrochloride;, N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl) -2-phenylpropanamide dihydrochloride

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关于此项目

经验公式（希尔记法）:
C24H33N3O2 · 2HCl
化学文摘社编号:
149055-79-8
分子量:
468.46
NACRES:
NA.77
PubChem Substance ID:
329830428
UNSPSC Code:
12352200
MDL number:
MFCD00903910

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InChI

1S/C24H33N3O2.2ClH/c1-24(2,3)25-23(28)20(19-10-6-5-7-11-19)18-26-14-16-27(17-15-26)21-12-8-9-13-22(21)29-4;;/h5-13,20H,14-18H2,1-4H3,(H,25,28);2*1H

SMILES string

Cl.Cl.COc1ccccc1N2CCN(CC2)CC(C(=O)NC(C)(C)C)c3ccccc3

InChI key

VJGZNBYDSDEOED-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

H2O: ≥10 mg/mL

originator

Wyeth

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

WAY-100135 is a potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). It is selective over 5-HT1B, 1C, 2,α1, α2 and D2 receptors (IC50 > 1000 nM).
WAY-100135 is a potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Selective over 5-HT1B,1C,2, α1, α2 and D2 receptors (IC50 > 1000 nM).

Features and Benefits

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000440913
0000440913
0000223296
0000223297
0000223297

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Kangjian Xiang et al.
Current neurovascular research, 13(4), 321-328 (2016-10-26)
Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that modulates N-methyl-D-aspartate (NMDA) receptor activity by binding to several different 5-HT receptor subtypes. In the present study, we used whole-cell patch-clamp recordings in transverse slice preparations to test the role of 5-HT
Daniel Sobrido-Cameán et al.
Disease models & mechanisms, 12(2) (2019-02-03)
Classical neurotransmitters are mainly known for their roles as neuromodulators, but they also play important roles in the control of developmental and regenerative processes. Here, we used the lamprey model of spinal cord injury to study the effect of serotonin
Lei Han et al.
The Journal of physiology, 599(1), 253-267 (2020-10-03)
Chemogenetic activation of medial vestibular nucleus-projecting 5-HT neurons resulted in deficits in vestibular-mediated tasks, including negative geotaxis, balance beam and rota-rod tests. The 5-HT1A receptor mediates the vestibular-related behavioural effects of 5-HT in the vestibular nucleus. 5-HT1A receptor activation attenuated

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