W3641
Anti-WSTF (N-Terminal) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-BAZ1B, Anti-Bromdomain Adjacent to Zn Finger Domain 1B, Anti-Williams Syndrome Transcription Factor, Anti-Williams-Beuren Syndrome Chromosome Region 9
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 175 kDa
species reactivity
human
technique(s)
immunoprecipitation (IP): 5-10 μg using from lysates of HEK293-T cells, western blot: 0.5-1 μg/mL using extracts of MCF-7 breast cancer cell line
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BAZ1B(9031)
mouse ... Baz1b(22385)
rat ... Baz1b(368002)
General description
The gene encoding Williams syndrome transcription factor (WSTF)/bromodomain adjacent to zinc finger domain 1B (BAZ1B), contains 20 exons extended over a length of 80kb on genomic DNA. The gene is localized on human chromosome 7q11.23. The encoded protein is composed of 1425 amino acids and is widely expressed in both adult and fetal tissues. WSTF contains one PHD-type zinc finger motif and a bromo domain.
Immunogen
synthetic peptide corresponding to amino acids 2-20 of human WSTF, conjugated to KLH via a C-terminal added cysteine residue. The sequence is conserved in human, mouse, and rat.
Application
Anti-WSTF (N-Terminal) antibody produced in rabbit has been used in sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).
Biochem/physiol Actions
Williams syndrome transcription factor (WSTF) acts as a key component of WICH (WSTF-ISWI chromatin remodeling complex) and the WINAC (WSTF including the nucleosome assembly complex). WICH and WINAC complexes plays a vital role in replication of heterochromatin and vitamin D-mediated transcription and replication, respectively. In addition, WSTF is also involved in neurodevelopment. Hemizygous deletion of the gene leads to a neurodevelopmental disorder, Williams syndrome (WS).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways
Lalli MA
Human Molecular Genetics, 25, 1294-1306 (2016)
A Novel Human Gene,WSTF,Is Deleted in Williams Syndrome
Lu X
Genomics, 54, 241-249 (1998)
The WSTF-SNF2h Chromatin Remodeling Complex Interacts with Several Nuclear Proteins in Transcription
Cavellan E
The Journal of Biological Chemistry, 281, 16264-16271 (2006)
Aleksandra Grochowska et al.
American journal of cancer research, 12(10), 4751-4763 (2022-11-17)
Bromodomain Adjacent to Zinc Finger Domain 1B (BAZ1B) is involved in multiple nuclear processes, and its role in tumorigenesis is emerging. However, the function of BAZ1B in colorectal cancer (CRC) remains largely unexplored. High-density tissue microarrays comprising 100 pairs of
Stephanie A Morris et al.
Nature structural & molecular biology, 21(1), 73-81 (2013-12-10)
ATP-dependent chromatin remodeling is an essential process required for the dynamic organization of chromatin structure. Here we describe the genome-wide location and activity of three remodeler proteins with diverse physiological functions in the mouse genome: Brg1, Chd4 and Snf2h. The
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