Quality Level
assay
≥98% (HPLC)
form
powder
color
white to brown
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
COc1cc(O)c-2c(OC(=O)c3c-2oc4cc(O)c(O)cc34)c1
InChI
1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
InChI key
XQDCKJKKMFWXGB-UHFFFAOYSA-N
Biochem/physiol Actions
蟛蜞菊内酯通过阻断 IκBα 的磷酸化和降解抑制细胞内的 NF-κB- 介导的基因转录。IKKα 和 β激酶活性不可逆抑制剂(IC 50 <10βM)。蟛蜞菊内酯对 p38 MAP 激酶或 Akt 没有影响。
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 1
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
相关内容
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The naturally occurring coumestan wedelolactone has been previously shown to reduce growth of various cancer cells. So far, the growth-suppressing effect of wedelolactone has been attributed to the inhibition of the NFκB transcription factor and/or androgen receptors. We found that
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Interleukin (IL)-6 plays a pivotal role in a variety of CNS functions such as the induction and modulation of reactive astrogliosis, pathological inflammatory responses and neuroprotection. Tumor necrosis factor (TNF)-alpha induces IL-6 release from rat C6 glioma cells through the
Zhimin Chen et al.
The Journal of biological chemistry, 288(20), 14417-14427 (2013-04-13)
Signal transducers and activators of transcription 1 (STAT1) transduces signals from cytokines and growth factors, particularly IFN-γ, and regulates expression of genes involved in cell survival/death, proliferation, and migration. STAT1 is activated through phosphorylation on its tyrosine 701 by JAKs
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| W4016-1MG | 04061826133309 |
