W4016
蟛蜞菊内酯
≥98% (HPLC), powder
别名:
1,8,9-三羟基-3-甲氧基-6 H -苯并呋喃 [3,2- c ] ] 苯并吡喃-6-酮, 5-甲氧基-5,11,12-三羟基香豆素
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to brown
溶解性
DMSO: 10 mg/mL, clear
储存温度
2-8°C
SMILES字符串
COc1cc(O)c-2c(OC(=O)c3c-2oc4cc(O)c(O)cc34)c1
InChI
1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
InChI key
XQDCKJKKMFWXGB-UHFFFAOYSA-N
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相关类别
生化/生理作用
蟛蜞菊内酯通过阻断 IκBα 的磷酸化和降解抑制细胞内的 NF-κB- 介导的基因转录。IKKα 和 β激酶活性不可逆抑制剂（IC 50 <10βM）。蟛蜞菊内酯对 p38 MAP 激酶或 Akt 没有影响。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 1
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Kumiko Tanabe et al.
Journal of neuroinflammation, 8, 68-68 (2011-06-21)
Peripheral-type benzodiazepine receptor (PBR) expression levels are low in normal human brain, but their levels increase in inflammation, brain injury, neurodegenerative states and gliomas. It has been reported that PBR functions as an immunomodulator. The mechanisms of action of midazolam
Zhimin Chen et al.
The Journal of biological chemistry, 288(20), 14417-14427 (2013-04-13)
Signal transducers and activators of transcription 1 (STAT1) transduces signals from cytokines and growth factors, particularly IFN-γ, and regulates expression of genes involved in cell survival/death, proliferation, and migration. STAT1 is activated through phosphorylation on its tyrosine 701 by JAKs
Petr Benes et al.
Cancer letters, 303(1), 29-38 (2011-02-15)
The naturally occurring coumestan wedelolactone has been previously shown to reduce growth of various cancer cells. So far, the growth-suppressing effect of wedelolactone has been attributed to the inhibition of the NFκB transcription factor and/or androgen receptors. We found that
Kumiko Tanabe et al.
Journal of neuroinflammation, 7, 16-16 (2010-03-09)
Interleukin (IL)-6 plays a pivotal role in a variety of CNS functions such as the induction and modulation of reactive astrogliosis, pathological inflammatory responses and neuroprotection. Tumor necrosis factor (TNF)-alpha induces IL-6 release from rat C6 glioma cells through the
Eclipta prostrata L. phytochemicals: isolation, structure elucidation, and their antitumor activity.
Qi-Mei Liu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(11), 4016-4022 (2012-08-21)
Eclipta prostrata L., (Asteraceae), is used in China for both food and medicine purposes. This research is concerned with the isolation and purification of phytochemical constituents from the aerial parts of E. prostrata, using gradient solvent fractionation, macroporous resin, silica
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