W4262
1400W 二盐酸盐
>98%, potent and selective iNOS inhibitor , solid
别名:
N-（[3-（氨基甲基）苯基]甲基）乙脒 二盐酸盐
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选择尺寸
关于此项目
经验公式（希尔记法）:
C10H15N3 · 2 HCl
化学文摘社编号:
分子量:
250.17
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
1400W 二盐酸盐, >98%, solid
SMILES string
Cl[H].Cl[H].CC(=N)NCc1cccc(CN)c1
InChI key
WDJHSQZCZGPGAA-UHFFFAOYSA-N
InChI
1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
assay
>98%
form
solid
storage condition
desiccated
originator
GlaxoSmithKline
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
human ... NOS1(4842), NOS2(4843), NOS3(4846)
Application
使用1400W二氢氯化物：
- 用作诱导型一氧化氮的强抑制剂，分析其对大鼠肠缺血再灌注(I/R)损伤模型的影响
- 用作诱导型一氧化氮合酶(iNOS)选择性抑制剂，说明PM10诱导型内皮功能障碍的机制
- 研究其对大鼠肾缺血/再灌注损伤的疗效
- 作为iNOS抑制剂，研究其在低压缺氧复氧后中和空间记忆障碍的能力
Biochem/physiol Actions
1400W 二盐酸盐是诱导型一氧化氮合酶（iNOS）的有效选择性抑制剂。
Features and Benefits
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Melatonin and 1400 W ameliorate both intestinal and remote organ injury following mesenteric ischemia/reperfusion
Kesik V, et al.
The Journal of Surgical Research, 157(1), e97-e105 (2009)
Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS
Ersoz N, et al.
Renal Failure, 31(8), 704-710 (2009)
L L Thomsen et al.
Cancer research, 57(15), 3300-3304 (1997-08-01)
We have investigated the effect of N-(3-(aminomethyl)benzyl)acetamidine (1400W), a novel and highly selective inhibitor for inducible NOS (iNOS), on in vivo growth of solid tumors expressing iNOS. For the EMT6 murine mammary adenocarcinoma, in which iNOS is expressed in the
E P Garvey et al.
The Journal of biological chemistry, 272(8), 4959-4963 (1997-02-21)
N-(3-(Aminomethyl)benzyl)acetamidine (1400W) was a slow, tight binding inhibitor of human inducible nitric- oxide synthase (iNOS). The slow onset of inhibition by 1400W showed saturation kinetics with a maximal rate constant of 0.028 s-1 and a binding constant of 2.0 microM.
Sandy Santos-Pereira et al.
PloS one, 14(12), e0226837-e0226837 (2019-12-20)
Leishmaniasis encompass a group of infectious parasitic diseases occurring in 97 endemic countries where over one billion people live in areas at risk of infection. It is in the World Health Organization list of neglected diseases and it is considered
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DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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