W4262
1400W 二盐酸盐
>98%, potent and selective iNOS inhibitor , solid
别名:
N-（[3-（氨基甲基）苯基]甲基）乙脒 二盐酸盐
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关于此项目
经验公式（希尔记法）:
C10H15N3 · 2 HCl
化学文摘社编号:
分子量:
250.17
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
1400W 二盐酸盐, >98%, solid
Quality Level
assay
>98%
form
solid
storage condition
desiccated
originator
GlaxoSmithKline
shipped in
wet ice
storage temp.
−20°C
SMILES string
Cl[H].Cl[H].CC(=N)NCc1cccc(CN)c1
InChI
1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
InChI key
WDJHSQZCZGPGAA-UHFFFAOYSA-N
Gene Information
human ... NOS1(4842), NOS2(4843), NOS3(4846)
Application
使用1400W二氢氯化物：
- 用作诱导型一氧化氮的强抑制剂，分析其对大鼠肠缺血再灌注(I/R)损伤模型的影响
- 用作诱导型一氧化氮合酶(iNOS)选择性抑制剂，说明PM10诱导型内皮功能障碍的机制
- 研究其对大鼠肾缺血/再灌注损伤的疗效
- 作为iNOS抑制剂，研究其在低压缺氧复氧后中和空间记忆障碍的能力
Biochem/physiol Actions
1400W 二盐酸盐是诱导型一氧化氮合酶（iNOS）的有效选择性抑制剂。
Features and Benefits
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
相关内容
Product Information Sheet
Simone Bido et al.
Nature communications, 12(1), 6237-6237 (2021-10-31)
Recent findings in human samples and animal models support the involvement of inflammation in the development of Parkinson's disease. Nevertheless, it is currently unknown whether microglial activation constitutes a primary event in neurodegeneration. We generated a new mouse model by
Jieyu Xu et al.
International journal of biological sciences, 16(9), 1563-1574 (2020-04-01)
The production of nitric oxide (NO) is a key feature of immunosuppressive myeloid cells, which impair T cell activation and proliferation via reversibly blocking interleukin-2 receptor signaling. NO is mainly produced from L-arginine by inducible NO synthase (iNOS). Moreover, L-arginine
Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS
Ersoz N, et al.
Renal Failure, 31(8), 704-710 (2009)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| W4262-10MG | 04061837540820 |