W4262
1400W 二盐酸盐
>98%, potent and selective iNOS inhibitor , solid
别名:
N-（[3-（氨基甲基）苯基]甲基）乙脒 二盐酸盐
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关于此项目
经验公式（希尔记法）:
C10H15N3 · 2 HCl
化学文摘社编号:
分子量:
250.17
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
1400W 二盐酸盐, >98%, solid
质量水平
方案
>98%
表单
solid
储存条件
desiccated
创始人
GlaxoSmithKline
运输
wet ice
储存温度
−20°C
SMILES字符串
Cl[H].Cl[H].CC(=N)NCc1cccc(CN)c1
InChI
1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
InChI key
WDJHSQZCZGPGAA-UHFFFAOYSA-N
基因信息
human ... NOS1(4842), NOS2(4843), NOS3(4846)
应用
使用1400W二氢氯化物：
- 用作诱导型一氧化氮的强抑制剂，分析其对大鼠肠缺血再灌注(I/R)损伤模型的影响
- 用作诱导型一氧化氮合酶(iNOS)选择性抑制剂，说明PM10诱导型内皮功能障碍的机制
- 研究其对大鼠肾缺血/再灌注损伤的疗效
- 作为iNOS抑制剂，研究其在低压缺氧复氧后中和空间记忆障碍的能力
生化/生理作用
1400W 二盐酸盐是诱导型一氧化氮合酶（iNOS）的有效选择性抑制剂。
特点和优势
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Simone Bido et al.
Nature communications, 12(1), 6237-6237 (2021-10-31)
Recent findings in human samples and animal models support the involvement of inflammation in the development of Parkinson's disease. Nevertheless, it is currently unknown whether microglial activation constitutes a primary event in neurodegeneration. We generated a new mouse model by
Jieyu Xu et al.
International journal of biological sciences, 16(9), 1563-1574 (2020-04-01)
The production of nitric oxide (NO) is a key feature of immunosuppressive myeloid cells, which impair T cell activation and proliferation via reversibly blocking interleukin-2 receptor signaling. NO is mainly produced from L-arginine by inducible NO synthase (iNOS). Moreover, L-arginine
E P Garvey et al.
The Journal of biological chemistry, 272(8), 4959-4963 (1997-02-21)
N-(3-(Aminomethyl)benzyl)acetamidine (1400W) was a slow, tight binding inhibitor of human inducible nitric- oxide synthase (iNOS). The slow onset of inhibition by 1400W showed saturation kinetics with a maximal rate constant of 0.028 s-1 and a binding constant of 2.0 microM.
L L Thomsen et al.
Cancer research, 57(15), 3300-3304 (1997-08-01)
We have investigated the effect of N-(3-(aminomethyl)benzyl)acetamidine (1400W), a novel and highly selective inhibitor for inducible NOS (iNOS), on in vivo growth of solid tumors expressing iNOS. For the EMT6 murine mammary adenocarcinoma, in which iNOS is expressed in the
Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS
Ersoz N, et al.
Renal Failure, 31(8), 704-710 (2009)
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