WH0003845M1
Anti-KRAS Antibody
mouse monoclonal, 3B10-2F2
别名:
抗CKRAS, 抗KIRAS, 抗KRAS1, 抗KRAS2, 抗KRAS2A, 抗KRAS2B, 抗KRAS4A, 抗KRAS4B, 抗RASK2, 抗v-Ki-ras2 Kirsten 大鼠肉瘤病毒癌基因同源物
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关于此项目
Conjugate:
unconjugated
Clone:
3B10-2F2, monoclonal
Application:
ELISA
capture ELISA
immunofluorescence
western blot
capture ELISA
immunofluorescence
western blot
Species reactivity:
human
Citations:
62
Technique(s):
ELISA: suitable
capture ELISA: suitable
immunofluorescence: suitable
western blot: 1-5 μg/mL
capture ELISA: suitable
immunofluorescence: suitable
western blot: 1-5 μg/mL
Uniprot accession no.:
产品名称
单克隆抗 KRAS 小鼠抗, clone 3B10-2F2, purified immunoglobulin, buffered aqueous solution
shipped in
dry ice
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3B10-2F2, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
ELISA: suitable
capture ELISA: suitable
immunofluorescence: suitable
western blot: 1-5 μg/mL
isotype
IgG1κ
GenBank accession no.
UniProt accession no.
application(s)
research pathology
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... KRAS(3845)
Application
小鼠抗 KRAS 单克隆抗体用于：免疫沉淀、免疫荧光、蛋白质印迹、 间接酶联免疫吸附测定（ELISA）。
Biochem/physiol Actions
Kirsten大鼠肉瘤病毒致癌基因同源物（KRAS）是Ras信号通路的关键蛋白。促进肿瘤侵袭和转移。该基因的功能获得性突变致使多种肿瘤发生，包括胰腺肿瘤、胆道肿瘤和结肠肿瘤。这种突变在胃癌中很少见到。
Disclaimer
除非我们的产品目录或产品随附的其他公司文件中另有说明，否则我们的产品仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。
General description
Kirsten大鼠肉瘤病毒癌基因同源物（KRAS）是癌基因，映射至人12p12.1染色体。选择性剪接产生编码两个同工型变体，在C末端区域不同。该基因编码小GTP酶超家族的成员。
Immunogen
KRAS (AAH13572，1 a.a.~188 a.a) 带有 GST 标签的全长重组蛋白。仅 GST 标签的分子量为 26 kDa。
序列
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKKKKSKTKCVIM
序列
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKKKKSKTKCVIM
Physical form
磷酸盐缓冲盐溶液，pH 7.4
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Loss of heterozygosity of chromosome 12p does not correlate with KRAS mutation in non-small cell lung cancer
Uchiyama M, et al.
International Journal of Cancer. Journal International Du Cancer, 107, 962-969 (2003)
Noise-reducing optogenetic negative-feedback gene circuits in human cells
Guinn MT, et al.
Nucleic Acids Research, 47, 7703-7714 (2019)
Michael Tyler Guinn et al.
Nucleic acids research, 47(14), 7703-7714 (2019-07-04)
Gene autorepression is widely present in nature and is also employed in synthetic biology, partly to reduce gene expression noise in cells. Optogenetic systems have recently been developed for controlling gene expression levels in mammalian cells, but most have utilized
Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies
Waters AM, et al.
Science Signaling, 10, 84826-84826 (2017)
Eusebio Manchado et al.
Nature, 534(7609), 647-651 (2016-06-25)
Therapeutic targeting of KRAS-mutant lung adenocarcinoma represents a major goal of clinical oncology. KRAS itself has proved difficult to inhibit, and the effectiveness of agents that target key KRAS effectors has been thwarted by activation of compensatory or parallel pathways
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