WH0005315M1
单克隆抗-PKM2 小鼠抗
clone 5D2-3B3, ascites fluid
别名:
抗-MGC3932, 抗-OIP3, 抗-PK3, 抗-PKM, 抗-TCB, 抗-THBP1, 抗-抗丙酮酸激酶，肌肉
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
5D2-3B3, monoclonal
Application:
ELISA (i), WB
Citations:
6
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
5D2-3B3, monoclonal
species reactivity
human
technique(s)
indirect ELISA: suitable, western blot: 1:500-1:1000
isotype
IgMκ
GenBank accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PKM2(5315)
General description
胚胎丙酮酸激酶M2（PKM2）是在哺乳动物中发现的丙酮酸激酶（PK）的异构体之一。它由定位至人类染色体15q23上的PKM2基因所编码。PKM2在除成人肌肉、大脑和肝脏以外的所有细胞中表达。该蛋白质通常以活性四聚体形式存在。
Immunogen
PKM2（AAH07640.1,1 a.a.约 531 a.a）具有 GST 标签的全长重组蛋白。仅 GST 标签的分子量为 26KDa。
序列
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
序列
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
Application
单克隆抗 PKM2 抗体可用于免疫印迹。
Biochem/physiol Actions
胚胎丙酮酸激酶M2（PKM2）控制β-连环蛋白（catenin）反式激活（transactivation）。它在有氧糖酵解或Warburg效应中起重要作用。PKM2可诱导基因转录和肿瘤发生。
Physical form
溶液
Legal Information
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis
Yang W, et al.
Cell (2014)
Pyruvate kinase isoenzyme M2 expression correlates with survival of cardiomyocytes after allogeneic rat heterotopic heart transplantation
Shi J, et al.
Pathology Research and Practice (2015)
The antioxidant uncoupling protein 2 stimulates hnRNPA2/B1, GLUT1 and PKM2 expression and sensitizes pancreas cancer cells to glycolysis inhibition
Brandi J, et al.
Free Radical Biology & Medicine, 101, 305-316 (2016)
Mutant p53 and mTOR/PKM2 regulation in cancer cells
Dando I, et al.
IUBMB Life, 68(9), 722-726 (2016)
Ilaria Dando et al.
IUBMB life, 68(9), 722-726 (2016-07-08)
Mutations of TP53 gene are the most common feature in aggressive malignant cells. In addition to the loss of the tumor suppressive role of wild-type p53, hotspot mutant p53 isoforms display oncogenic proprieties notoriously referred as gain of functions (GOFs)
商品
Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.
本页面介绍了一篇有关瓦博格效应的文章，以及其如何能够在正常氧气水平下，增强肿瘤细胞中葡萄糖向乳酸的转化。Otto Heinrich Warburg在1924年证明，癌细胞显示出对糖酵解的依赖性增加，以满足他们的能量需求，无论是否有充足的氧气存在。
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