WH0005692M1
Monoclonal Anti-PSMB4 antibody produced in mouse
clone 6G7-E8, purified immunoglobulin, buffered aqueous solution
别名:
Anti-HN3, Anti-HsN3, Anti-PROS26, Anti-proteasome (prosome, macropain) subunit, beta type, 4
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
6G7-E8, monoclonal
Application:
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
indirect ELISA
western blot
indirect ELISA
western blot
Species reactivity:
human
Citations:
5
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL
indirect ELISA: suitable
western blot: 1-5 μg/mL
Uniprot accession no.:
产品名称
Monoclonal Anti-PSMB4 antibody produced in mouse, clone 6G7-E8, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
6G7-E8, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL
isotype
IgG1κ
GenBank accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PSMB4(5692)
Biochem/physiol Actions
Proteasome subunit β 4 (PSMB4) associates with senescence evasion factor (SNEV), various signaling factors, viral proteins and lipopolysaccharides. It modulates the assembly of the proteasome and may be involved in proteasome signal regulation. PSMB4 has a role in the progression of epithelial ovarian cancer and many other types of cancers.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Proteasome subunit β 4 (PSMB4), also referred to as 20S proteasome subunit β-7, is a non-catalytic β subunit of the 20S proteasome. It is composed of 233 amino acids and the gene encoding it is localized on human chromosome 1q21.3.
Immunogen
PSMB4 (AAH00331, 1 a.a. ~ 264 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQTATVTEKGVEIEGPLSTETNWDIAHMISGFE
Sequence
MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQTATVTEKGVEIEGPLSTETNWDIAHMISGFE
Physical form
Solution in phosphate buffered saline, pH 7.4
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes
Genne Y
Cancer Research (2014)
The ubiquitin-proteasome system and chromosome 17 in cerebellar granule cells and medulloblastoma subgroups
Jerry V
Cellular and Molecular Life Sciences (2016)
PSMB4 expression associates with epithelial ovarian cancer growth and poor prognosis.
Archives of Gynecology and Obstetrics (2016)
Cloning and expression of a human pro(tea)some beta-subunit cDNA: a homologue of the yeast PRE4-subunit essential for peptidylglutamyl-peptide hydrolase activity.
Gerards WL
Febs Letters (1994)
Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome.
Losher M
The Biochemical Journal (2005)
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