WH0005725M1
抗 PTBP1 单克隆抗体 小鼠抗
clone 3H8, purified immunoglobulin, buffered aqueous solution
别名:
抗-HNRNPI, 抗-HNRPI, 抗-MGC10830, 抗-MGC8461, 抗-PTB, 抗-PTB1, 抗-PTB2, 抗-PTB3, 抗-PTB4, 抗-PTBT, 抗-pPTB, 抗-多嘧啶束结合蛋白1
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关于此项目
Conjugate:
unconjugated
Clone:
3H8, monoclonal
Application:
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
immunoprecipitation (IP)
indirect ELISA
indirect immunofluorescence
western blot
immunoprecipitation (IP)
indirect ELISA
indirect immunofluorescence
western blot
Species reactivity:
human
Citations:
7
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL
immunoprecipitation (IP): suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL
Uniprot accession no.:
产品名称
抗 PTBP1 单克隆抗体 小鼠抗, clone 3H8, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3H8, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL
isotype
IgG1κ
GenBank accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PTBP1(5725)
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
该基因属于普遍表达的异质核糖核蛋白（hnRNPs）的亚家族。hnRNP是RNA结合蛋白，其与异质核RNA（hnRNA）形成复合物。这些蛋白质与细胞核中的前mRNA相关，并且似乎影响前mRNA的加工以及mRNA代谢和转运的其他方面。尽管所有hnRNP存在于细胞核中，但有些似乎在细胞核和细胞质之间穿梭。hnRNP蛋白具有独特的核酸结合特性。该基因编码的蛋白质具有结合RNA的准RNA识别基序（RRM）域的四个重复序列。该蛋白质与需要前mRNA剪接的内含子聚嘧啶束结合，并通过蛋白质降解泛素-蛋白酶体途径起作用。它也可能促进U2 snRNP与前mRNA的结合。该蛋白位于核质中，也可以在核仁周围结构中检测到。已经描述了编码不同亚型的选择性剪接的转录变体。（由RefSeq提供）
Immunogen
PTBP1（NP_002810, 45 a.a.~ 144 a.a）带有GST标签的部分重组蛋白。仅GST标签的MW为26 KDa。
序列
KKFKGDSRSAGVPSRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKTDSSPNQ
序列
KKFKGDSRSAGVPSRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKTDSSPNQ
Physical form
溶于pH7.4的磷酸盐缓冲盐水中的溶液
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Endothelial deletion of PTBP1 disrupts ventricular chamber development.
Liu, et al.
Nature Communications, 14, 1796-1796 (2023)
Alfredo Castello et al.
Nature protocols, 8(3), 491-500 (2013-02-16)
Owing to their preeminent biological functions, the repertoire of expressed RNA-binding proteins (RBPs) and their activity states are highly informative about cellular systems. We have developed a novel and unbiased technique, called interactome capture, for identifying the active RBPs of
Global analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture.
Joel I Perez-Perri et al.
Nature protocols, 16(1), 27-60 (2020-11-20)
Interactions between RNA-binding proteins (RBPs) and RNAs are critical to cell biology. However, methods to comprehensively and quantitatively assess these interactions within cells were lacking. RNA interactome capture (RIC) uses in vivo UV crosslinking, oligo(dT) capture, and proteomics to identify
Xueying Zhai et al.
Autophagy, 19(8), 2338-2352 (2023-03-03)
Macroautophagy/autophagy is a cellular degradation and recycling process that maintains the homeostasis of organisms. The protein degradation role of autophagy has been widely used to control viral infection at multiple levels. In the ongoing evolutionary arms race, viruses have developed
Raul Guantes et al.
Genome research, 25(5), 633-644 (2015-03-25)
Noise in gene expression is a main determinant of phenotypic variability. Increasing experimental evidence suggests that genome-wide cellular constraints largely contribute to the heterogeneity observed in gene products. It is still unclear, however, which global factors affect gene expression noise
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