WH0055288M1
抗-RHOT1单克隆抗体 小鼠抗
clone 4H4, purified immunoglobulin, buffered aqueous solution
别名:
抗- ras 同源基因族，成员T1, 抗-ARHT1, 抗-FLJ11040, 抗-FLJ12633, 抗-MIRO1
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
4H4, monoclonal
表单
buffered aqueous solution
种属反应性
human
技术
indirect ELISA: suitable
western blot: 1-5 μg/mL
同位素/亚型
IgG1κ
GenBank登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... RHOT1(55288)
一般描述
Ras同源物家族成员T1（RHOT1）由位于人染色体 17q11.2的基因编码。RhoT1是线粒体Rho GTPase家族成员。
免疫原
带GST标签的RHOT1（NP_060777，483 a.a. ~ 580 a.a）部分重组蛋白。GST标签的分子量为26 KDa。
序列
TEAEIICDVVCLVYDVSNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEYSISPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYP
序列
TEAEIICDVVCLVYDVSNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEYSISPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYP
生化/生理作用
Ras同源物家族成员T1（RHOT1）在线粒体稳态和细胞凋亡的控制中起着至关重要的作用。RHOT1 可作为胰腺癌（PC）的肿瘤抑制基因，它被认为是总体生存率的潜在预后生物标志物，也有望成为PC治疗靶点。RHOT1表达的下降可能导致淋巴结转移（LNM）和较短的生存期。RHOT1在线粒体运输、淋巴细胞迁移和极性中发挥重要作用。
外形
溶于pH7.4的磷酸盐缓冲盐水中的溶液
法律信息
GenBank is a registered trademark of United States Department of Health and Human Services
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Renu Bajaj et al.
Molecular cytogenetics, 4, 3-3 (2011-01-22)
To evaluate the clinical validity of genome-wide oligonucleotide array comparative genomic hybridization (aCGH) for detecting somatic abnormalities, we have applied this genomic analysis to 30 cases (13 MDS and 17 AML) with clonal chromosomal abnormalities detected in more than 50%
RhoT1 and Smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer.
Hua Jiang et al.
PloS one, 7(7), e42234-e42234 (2012-08-04)
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There is a lack of reliable molecular markers for Parkinson's disease (PD) patients and at-risk individuals. The detection of the pre-symptomatic population of PD will empower more effective clinical intervention to delay or prevent disease onset. We have previously found
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