WH0148581M7
Monoclonal Anti-UBE2U antibody produced in mouse
clone 3D4, purified immunoglobulin, buffered aqueous solution
别名:
Anti-MGC35130, Anti-RP4636O23.1, Anti-ubiquitin-conjugating enzyme E2U (putative)
产品名称
Monoclonal Anti-UBE2U antibody produced in mouse, clone 3D4, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3D4, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunofluorescence: suitable
indirect ELISA: suitable
isotype
IgG2aκ
GenBank accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... UBE2U(148581)
Biochem/physiol Actions
UBE2U (Ubiquitin-conjugating enzyme E2U) plays a vital role in the formation of E2-RING E3 network in the human ubiquitin-proteasome system. It acts as a hub protein in direct interaction with E3 ligase, MDM2. It links and holds E2-E3 network together for the ubiquitination activity, which finally transfer the ubiquitin to the E3-bound substrate. The protein also plays a role in the protein degradation process of misfolded and short-lived proteins.
General description
UBE2U (Ubiquitin-conjugating enzyme E2U) is an E2 enzyme belonging to the class III group of UbcH5 family of highly homologous E2s family. It consists of an extended C-terminal tail region attached to its UBC-fold. Its mRNA expression has been reported in the urogenital tract.
Immunogen
UBE2U (NP_689702.1, 9 a.a. ~ 102 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
LHRDFCDLKENNYKGITAKPVSEDMMEWEVEIEGLQNSVWQGLVFQLTIHFTSEYNYAPPVVKFITIPFHPNVDPHTGQPCIDFLDNPEKWNTN
Sequence
LHRDFCDLKENNYKGITAKPVSEDMMEWEVEIEGLQNSVWQGLVFQLTIHFTSEYNYAPPVVKFITIPFHPNVDPHTGQPCIDFLDNPEKWNTN
Physical form
Solution in phosphate buffered saline, pH 7.4
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Sjoerd J L van Wijk et al.
Molecular systems biology, 5, 295-295 (2009-08-20)
Covalent attachment of ubiquitin to substrates is crucial to protein degradation, transcription regulation and cell signalling. Highly specific interactions between ubiquitin-conjugating enzymes (E2) and ubiquitin protein E3 ligases fulfil essential roles in this process. We performed a global yeast-two hybrid
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