WH0148581M7
Monoclonal Anti-UBE2U antibody produced in mouse
clone 3D4, purified immunoglobulin, buffered aqueous solution
别名:
Anti-MGC35130, Anti-RP4636O23.1, Anti-ubiquitin-conjugating enzyme E2U (putative)
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
3D4, monoclonal
表单
buffered aqueous solution
种属反应性
human
技术
immunofluorescence: suitable
indirect ELISA: suitable
同位素/亚型
IgG2aκ
GenBank登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... UBE2U(148581)
一般描述
UBE2U (Ubiquitin-conjugating enzyme E2U) is an E2 enzyme belonging to the class III group of UbcH5 family of highly homologous E2s family. It consists of an extended C-terminal tail region attached to its UBC-fold. Its mRNA expression has been reported in the urogenital tract.
免疫原
UBE2U (NP_689702.1, 9 a.a. ~ 102 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
LHRDFCDLKENNYKGITAKPVSEDMMEWEVEIEGLQNSVWQGLVFQLTIHFTSEYNYAPPVVKFITIPFHPNVDPHTGQPCIDFLDNPEKWNTN
Sequence
LHRDFCDLKENNYKGITAKPVSEDMMEWEVEIEGLQNSVWQGLVFQLTIHFTSEYNYAPPVVKFITIPFHPNVDPHTGQPCIDFLDNPEKWNTN
生化/生理作用
UBE2U (Ubiquitin-conjugating enzyme E2U) plays a vital role in the formation of E2-RING E3 network in the human ubiquitin-proteasome system. It acts as a hub protein in direct interaction with E3 ligase, MDM2. It links and holds E2-E3 network together for the ubiquitination activity, which finally transfer the ubiquitin to the E3-bound substrate. The protein also plays a role in the protein degradation process of misfolded and short-lived proteins.
外形
Solution in phosphate buffered saline, pH 7.4
法律信息
GenBank is a registered trademark of United States Department of Health and Human Services
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Sjoerd J L van Wijk et al.
Molecular systems biology, 5, 295-295 (2009-08-20)
Covalent attachment of ubiquitin to substrates is crucial to protein degradation, transcription regulation and cell signalling. Highly specific interactions between ubiquitin-conjugating enzymes (E2) and ubiquitin protein E3 ligases fulfil essential roles in this process. We performed a global yeast-two hybrid
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