WH0246243M1
Monoclonal Anti-RNASEH1 antibody produced in mouse
clone 5D10, purified immunoglobulin, buffered aqueous solution
别名:
Anti-H1RNA, Anti-ribonuclease H1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
5D10, monoclonal
Application:
indirect ELISA
western blot
western blot
Species reactivity:
human, rat, mouse
Citations:
4
Technique(s):
indirect ELISA: suitable
western blot: 1-5 μg/mL
western blot: 1-5 μg/mL
Uniprot accession no.:
产品名称
Monoclonal Anti-RNASEH1 antibody produced in mouse, clone 5D10, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
5D10, monoclonal
form
buffered aqueous solution
species reactivity
human, rat, mouse
technique(s)
indirect ELISA: suitable
western blot: 1-5 μg/mL
isotype
IgG2aκ
GenBank accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... RNASEH1(246243)
Biochem/physiol Actions
Ribonuclease H1 (RNASEH1) digests the RNA segment in a DNA-RNA hybrid. Mutations in the gene encoding it have been associated with chronic progressive external ophthalmoplegia.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Ribonuclease H1 (RNASEH1) is an endonuclease which is expressed in the mitochondria and nucleus. It possesses two domains which aid in binding to nucleic acids. The gene encoding this protein is localized on human chromosome 2p25.
Immunogen
RNASEH1 (NP_002927, 189 a.a. ~ 286 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
AACKAIEQAKTQNINKLVLYTDSMFTINGITNWVQGWKKNGWKTSAGKEVINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAKQSED
Sequence
AACKAIEQAKTQNINKLVLYTDSMFTINGITNWVQGWKKNGWKTSAGKEVINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAKQSED
Physical form
Solution in phosphate buffered saline, pH 7.4
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Aurelio Reyes et al.
American journal of human genetics, 97(1), 186-193 (2015-06-23)
Chronic progressive external ophthalmoplegia (CPEO) is common in mitochondrial disorders and is frequently associated with multiple mtDNA deletions. The onset is typically in adulthood, and affected subjects can also present with general muscle weakness. The underlying genetic defects comprise autosomal-dominant
E J Devor et al.
The Journal of heredity, 95(3), 257-261 (2004-06-29)
A retroprocessed pseudogene (retropseudogene) descended from the gene encoding ribonuclease (RNase) H1 has been found in ape genomes that preserves a splice junction mutation event that altered the carboxyl-terminal end of the enzyme. The GT --> GC transition mutant at
Christopher N Johnson et al.
Biochemistry, 50(19), 3903-3912 (2011-03-30)
Numerous DNA chemistries for improving oligodeoxynucleotide (ODN)-based RNA targeting have been explored. The majority of the modifications render the ODN/RNA target insensitive to RNase H1. Borano phosphonate ODN's are among the few modifications that are tolerated by RNase H1. To
So Hae Park et al.
Nucleic acids research, 49(13), 7507-7524 (2021-06-29)
Impaired replication progression leads to de novo copy number variant (CNV) formation at common fragile sites (CFSs). We previously showed that these hotspots for genome instability reside in late-replicating domains associated with large transcribed genes and provided indirect evidence that
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