WH0414899M5
Monoclonal Anti-BRCC2 antibody produced in mouse
clone 3F4, purified immunoglobulin, buffered aqueous solution
别名:
Anti-BRCC2
生物来源
mouse
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
3F4, monoclonal
表单
buffered aqueous solution
种属反应性
human
技术
immunofluorescence: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL
同位素/亚型
IgG2aκ
GenBank登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... BLID(414899)
一般描述
This gene encodes a BH3-like motif containing protein involved in cell death. The encoded protein may induce apoptosis in a caspase-dependent manner. The protein is localized in both the cytoplasm and the mitochondrion. [SH
免疫原
BRCC2 (NP_001001786, 2 a.a. ~ 108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
VTLLPIEGQEVHFFEILESECVLYTGWIERASGSSIYPEAKARLPLEALLGSNKEPMLPKETVLSLKRYNLGSSAMKRNVPGHVLQRPSYLTRIQVTLLCNSSAEAL
Sequence
VTLLPIEGQEVHFFEILESECVLYTGWIERASGSSIYPEAKARLPLEALLGSNKEPMLPKETVLSLKRYNLGSSAMKRNVPGHVLQRPSYLTRIQVTLLCNSSAEAL
生化/生理作用
BRCC2 or BH3-like motif containing, cell death inducer acts as a tumor suppressor by modulating the AKT8 virus oncogene cellular homolog (Akt) pathway in breast cancer tissue. It associates with Bcl-2 long isoform (BCL-XL). BRCC2 also stimulates the caspase-dependent mitochondrial cell death pathway.
特点和优势
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外形
Solution in phosphate buffered saline, pH 7.4
法律信息
GenBank is a registered trademark of United States Department of Health and Human Services
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
BRCC2 inhibits breast cancer cell growth and metastasis in vitro and in vivo via downregulating AKT pathway.
Li X
Cell Death & Disease, 4, e757-e757 (2013)
Frequent loss of the BLID gene in early-onset breast cancer.
Cavalli LR
Cytogenetic and genome research, 135(1), 19-24 (2011)
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