X0629
Anti-XRCC1 兔抗
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-X-ray repair complementing defective repair in Chinese hamster cells 1
产品名称
Anti-XRCC1 兔抗, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 85 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
indirect immunofluorescence: 5-10 μg/mL using MCF7 cells fixed with paraformaldehyde-Triton
western blot: 0.5-1 μg/mL using A431 cell lysates
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... XRCC1(7515)
mouse ... Xrcc1(22594)
rat ... Xrcc1(84495)
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Application
Anti-XRCC1 antibody produced in rabbit has been used in:
- immunoblotting
- immunofluorescence
- indirect immunofluorescence and telomere FISH (TEL-FISH)
- protein detection
- western analysis
Biochem/physiol Actions
X-ray repair cross-complementing group 1 (XRCC1) is a molecular scaffold protein that coordinates the assembly of repair complexes at damaged sites. XRCC has been shown to physically interact with several enzymes known to be involved in the repair of SSBs, including DNA ligase IIIa, DNA polymerase b, APE1, polynucleotide kinase (PNK), poly (ADP-ribose), polymerases 1 and 2 (PARP-1 and 2) and others. It participates in the DNA base excision repair (BER) pathway.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
X-ray repair cross-complementing group 1 (XRCC1) is a testis enriched protein. It is considered as a DNA repair gene.
Immunogen
synthetic peptide corresponding to amino acids 615-633 of human XRCC1, conjugated to KLH via an N-terminal added cysteine residue. The immunizing peptide is identical in mouse and rat.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
XRCC1 deficiency correlates with increased DNA damage and male infertility
Singh V, et al.
Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 839 (2019)
XRCC1 deficiency correlates with increased DNA damage and male infertility
Singh V, et al.
Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 839, 1-8 (2019)
XRCC1 polymorphism and overall survival in ovarian cancer patients treated with platinum-based chemotherapy: A systematic review and MOOSE-compliant meta-analysis
Zhang Z, et al.
Medicine, 97(45) (2018)
Versatile recombinant SUMOylation system for the production of SUMO-modified protein
Weber AR, et al.
PLoS ONE, 9(7), e102157-e102157 (2014)
Characterization of oxidative guanine damage and repair in mammalian telomeres
Wang Z, et al.
PLoS Genetics, 6(5), e1000951-e1000951 (2010)
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持