X1129
Anti-XPC (C-terminal) 兔抗
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-Xeroderma pigmentosum, complementary group C, Anti-XP3, Anti-XPCC
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 120 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
indirect immunofluorescence: 5-10 μg/mL using MCF7 cells fixed with paraformaldehyde-Triton, western blot: 0.5-1 μg/mL using MCF-7 cell lysates
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... XPC(7508)
General description
DNA damage recognition and repair factor, XPC complex subunit xeroderma pigmentosum group C (XPC) is a DNA damage recognition factor. The protein consists of 940 amino acids. The gene encoding XPC is localized on human chromosome 3p25.1 and consists of 18 exons.
XPC exists in vivo as a heterotrimeric complex with one of the two mammalian homologs of S. cerevisiae Rad23 (HR23A or HR23B) and centrin 2.
Immunogen
synthetic peptide corresponding to amino acids 922-940 of human XPC, conjugated to KLH via an N-terminal added cysteine residue.
Application
Anti-XPC (C-terminal) antibody produced in rabbit has been used in indirect immunofluorescence and western blotting
Biochem/physiol Actions
DNA damage recognition and repair factor, XPC complex subunit xeroderma pigmentosum group C (XPC) has a role in global genome nucleotide excision repair pathway. As part of the XPC complex, this protein binds to DNA sites having many lesions. Single nucleotide polymorphisms in the XPC gene have been linked to various cancers.
Defective XPC gene causes photosensitivity syndrome called xeroderma pigmentosum (XP), which is characterized by a very high incidence of light-induced skin cancer.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Nucleotide excision repair as a marker for susceptibility to tobacco-related cancers: a review of molecular epidemiological studies
Neumann AS, et al.
Molecular Carcinogenesis, 42(2), 65-92 (2005)
Nucleotide excision repair in E. coli and man
Advances in Protein Chemistry, 69, 43-71 (2004)
Faster DNA repair of ultraviolet-induced cyclobutane pyrimidine dimers and lower sensitivity to apoptosis in human corneal epithelial cells than in epidermal keratinocytes
Mallet JD, et al.
PLoS ONE, 11(9), e0162212-e0162212 (2016)
Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair
Araki M, et al.
Test, 276(22), 18665-18672 (2001)
Justin D Mallet et al.
PloS one, 11(9), e0162212-e0162212 (2016-09-10)
Absorption of UV rays by DNA generates the formation of mutagenic cyclobutane pyrimidine dimers (CPD) and pyrimidine (6-4) pyrimidone photoproducts (6-4PP). These damages are the major cause of skin cancer because in turn, they can lead to signature UV mutations.
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