X4879
Xaliproden
≥97% (HPLC), solid
别名:
1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]pyridine 盐酸盐, SR-57746A
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关于此项目
经验公式（希尔记法）:
C24H22F3N · HCl
化学文摘社编号:
分子量:
417.89
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C24H22F3N.ClH/c25-24(26,27)23-7-3-6-22(17-23)20-11-14-28(15-12-20)13-10-18-8-9-19-4-1-2-5-21(19)16-18;/h1-9,11,16-17H,10,12-15H2;1H
SMILES string
Cl.FC(F)(F)c1cccc(c1)C2=CCN(CCc3ccc4ccccc4c3)CC2
InChI key
WVHBEIJGAINUBW-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
solid
color
white to off-white
solubility
DMSO: ≥5 mg/mL
originator
Sanofi Aventis
storage temp.
2-8°C
Quality Level
Gene Information
human ... HTR1A(3350)
相关类别
Biochem/physiol Actions
5-HT1A serotonin receptor agonist; neuroprotectant
Features and Benefits
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Sherry Wolf et al.
European journal of cancer (Oxford, England : 1990), 44(11), 1507-1515 (2008-06-24)
Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose limiting side effect of many commonly used chemotherapeutic agents, including platinum drugs, taxanes, epothilones and vinca alkaloids, and also newer agents such as bortezomib and lenolidamide. Symptom control studies have been conducted
P Murali Doraiswamy et al.
Expert opinion on pharmacotherapy, 7(1), 1-10 (2005-12-24)
This review examines key pharmacological strategies that have been clinically studied for the primary or secondary prevention of Alzheimer's disease. Much information (neuropsychological, genetic and imaging) is already available to characterise an individual's risk for developing Alzheimer's disease. However, regulatory
A Appert-Collin et al.
International journal of immunopathology and pharmacology, 18(1), 21-31 (2005-02-09)
Motoneurons require neurotrophic factors for their survival and their differentiation. Xaliproden (SR57746A) is a synthetic compound that exhibits in vivo and in vitro neurotrophic effects in several experimental studies. Here we demonstrate that neuroprotective effects of Xaliproden on motoneuron cultures
M Magazin et al.
Brain research. Molecular brain research, 53(1-2), 301-306 (1998-04-29)
Rapid neurite retraction and transient rounding of serum-starved NG108-15 and PC12 cells by lysophosphatidic acid (LPA) is retarded and reduced by pre-incubation of the cells with the small non-peptidic molecule, SR 57746A, which exhibits neurotrophic properties. The compound also antagonizes
Highlights From: the 2006 American Society of Clinical Oncology Gastrointestinal Cancers Symposium San Francisco, CA, January 2006.
Tara Beers Gibson et al.
Clinical colorectal cancer, 5(6), 398-402 (2006-04-26)
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