X4879
Xaliproden
≥97% (HPLC), solid
别名:
1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]pyridine 盐酸盐, SR-57746A
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关于此项目
经验公式（希尔记法）:
C24H22F3N · HCl
化学文摘社编号:
分子量:
417.89
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
Xaliproden, ≥97% (HPLC), solid
InChI
1S/C24H22F3N.ClH/c25-24(26,27)23-7-3-6-22(17-23)20-11-14-28(15-12-20)13-10-18-8-9-19-4-1-2-5-21(19)16-18;/h1-9,11,16-17H,10,12-15H2;1H
SMILES string
Cl.FC(F)(F)c1cccc(c1)C2=CCN(CCc3ccc4ccccc4c3)CC2
InChI key
WVHBEIJGAINUBW-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
solid
color
white to off-white
solubility
DMSO: ≥5 mg/mL
originator
Sanofi Aventis
storage temp.
2-8°C
Quality Level
Gene Information
human ... HTR1A(3350)
相关类别
Biochem/physiol Actions
5-HT1A serotonin receptor agonist; neuroprotectant
Features and Benefits
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
A Appert-Collin et al.
International journal of immunopathology and pharmacology, 18(1), 21-31 (2005-02-09)
Motoneurons require neurotrophic factors for their survival and their differentiation. Xaliproden (SR57746A) is a synthetic compound that exhibits in vivo and in vitro neurotrophic effects in several experimental studies. Here we demonstrate that neuroprotective effects of Xaliproden on motoneuron cultures
A Appert-Collin et al.
International journal of immunopathology and pharmacology, 17(2), 157-164 (2004-06-03)
Compounds possessing neurotrophic properties may represent a possible treatment for neurodegenerative disorders such as amyotrophic lateral sclerosis. Xaliproden (SR57746A), an orally-active non-peptide compound, which has been found to exhibit neurotrophic effects in vitro and in vivo, increased the lifespan and
J P Terranova et al.
Neuroscience letters, 213(2), 79-82 (1996-08-02)
Different putative toxic amyloid beta (A beta) peptides, beta (1-42), beta (1-40) and beta (25-35), were infused (0.75, 1.5 or 3 nmol) in the rat medial septum. Memory deficits were then investigated using the social recognition test. A significant amnesia
P Murali Doraiswamy et al.
Expert opinion on pharmacotherapy, 7(1), 1-10 (2005-12-24)
This review examines key pharmacological strategies that have been clinically studied for the primary or secondary prevention of Alzheimer's disease. Much information (neuropsychological, genetic and imaging) is already available to characterise an individual's risk for developing Alzheimer's disease. However, regulatory
Highlights From: the 2006 American Society of Clinical Oncology Gastrointestinal Cancers Symposium San Francisco, CA, January 2006.
Tara Beers Gibson et al.
Clinical colorectal cancer, 5(6), 398-402 (2006-04-26)
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