Y4895
YM-58483
≥98% (HPLC)
别名:
4-甲基-4′-[3,5-双(三氟甲基)-1H-吡唑-1-基]-1,2,3-噻二唑-5-甲酰苯胺
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选择尺寸
关于此项目
经验公式（希尔记法）:
C15H9F6N5OS
化学文摘社编号:
分子量:
421.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
YM-58483, ≥98% (HPLC)
InChI key
XPRZIORDEVHURQ-UHFFFAOYSA-N
SMILES string
Cc1nnsc1C(=O)Nc2ccc(cc2)-n3nc(cc3C(F)(F)F)C(F)(F)F
InChI
1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Application
YM-58483已被用于心肌细胞和肺动脉内皮细胞中存在的钙通道的抑制研究。
Biochem/physiol Actions
YM-58483是一种选择性的Ca++释放激活的Ca++（CRAC）[即库操纵性Ca++（SOC）通道]，可介导Ca++流入T细胞和其他炎症细胞。CRAC通道抑制剂在自身免疫性疾病、移植排斥、气道过敏和支气管哮喘中具有潜在的临床应用。YM-58483也被推广为一种CRAC研究的工具；可用作金标准。
选择性库操纵性钙（SOC）通道抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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