Y4895
YM-58483
≥98% (HPLC)
别名:
4-甲基-4′-[3,5-双(三氟甲基)-1H-吡唑-1-基]-1,2,3-噻二唑-5-甲酰苯胺
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C15H9F6N5OS
化学文摘社编号:
分子量:
421.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
YM-58483, ≥98% (HPLC)
InChI key
XPRZIORDEVHURQ-UHFFFAOYSA-N
SMILES string
Cc1nnsc1C(=O)Nc2ccc(cc2)-n3nc(cc3C(F)(F)F)C(F)(F)F
InChI
1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Application
YM-58483已被用于心肌细胞和肺动脉内皮细胞中存在的钙通道的抑制研究。
Biochem/physiol Actions
YM-58483是一种选择性的Ca++释放激活的Ca++（CRAC）[即库操纵性Ca++（SOC）通道]，可介导Ca++流入T细胞和其他炎症细胞。CRAC通道抑制剂在自身免疫性疾病、移植排斥、气道过敏和支气管哮喘中具有潜在的临床应用。YM-58483也被推广为一种CRAC研究的工具；可用作金标准。
选择性库操纵性钙（SOC）通道抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Sodium entry through endothelial store-operated calcium entry channels: regulation by Orai1
Xu N, et al.
American Journal of Physiology. Cell Physiology, 308(4), C277-C288 (2014)
Data on calcium increases depending on stretch in dystrophic cardiomyocytes
Aguettaz E et al.
Data in Brief, 8, 1443-1447 (2016)
Estella Zuccolo et al.
Stem cells and development, 27(1), 23-34 (2017-11-11)
Stromal cell-derived factor-1α (SDF-1α) drives endothelial colony-forming cell (ECFC) homing and incorporation within neovessels, thereby restoring tissue perfusion in ischemic tissues and favoring tumor vascularization and metastasis. SDF-1α stimulates ECFC migration by activating the G
Sergei G Gaidin et al.
Glia, 68(6), 1114-1130 (2019-12-20)
Norepinephrine is one of the key neurotransmitters in the hippocampus, but its role in the functioning of the neuroglial networks remains unclear. Here we show that norepinephrine suppresses NH4 Cl-induced oscillations of the intracellular Ca2+ concentration ([Ca2+ ]i ) in
Ling Hai et al.
Nature communications, 15(1), 968-968 (2024-02-07)
Tumor microtubes (TMs) connect glioma cells to a network with considerable relevance for tumor progression and therapy resistance. However, the determination of TM-interconnectivity in individual tumors is challenging and the impact on patient survival unresolved. Here, we establish a connectivity
商品
We offers many products related to calcium channels for your research needs.
我们提供多种与钙通道相关的产品以满足您的各类研究需求。
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持