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Z0153

ZM 241385

Name: ZM 241385
Brand: SIGMA

≥98% (HPLC), adenosine A2A antagonist, powder

别名:

4-(-2-[7-氨基-2-{2-呋喃基}{1,2,4}三唑并{2,3-a}{1,3,5}三嗪-5-基-氨基]乙基)苯酚

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关于此项目

经验公式（希尔记法）:

C₁₆H₁₅N₇O₂

化学文摘社编号:

139180-30-6

分子量:

337.34

UNSPSC Code:

12352200

PubChem Substance ID:

329831597

NACRES:

NA.77

MDL number:

MFCD00908394

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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产品名称

ZM 241385, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: >15 mg/mL

storage temp.

room temp

SMILES string

Nc1nc(NCCc2ccc(O)cc2)nc3nc(nn13)-c4ccco4

InChI

1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)

InChI key

PWTBZOIUWZOPFT-UHFFFAOYSA-N

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Biochem/physiol Actions

ZM 241385是一种有效的选择性腺苷A2A拮抗剂。

ZM 241385是一种有效的选择性腺苷A2A拮抗剂。A2A受体可在调节心肌耗氧量和冠状动脉血流中起作用，并在脑中高度表达，并在此发挥重要的谷氨酸和多巴胺释放调节作用。 ZM 241385具有神经保护作用，正被研究用于帕金森病和其他神经退行性疾病。

Features and Benefits

《受体分类和信号转导》手册的腺苷受体页有该化合物的介绍。想要浏览手册的其他页面，请单击此处。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000518454

0000514974

0000514971

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Potential therapeutic effects of antagonizing adenosine A2A receptor, curcumin and niacin in rotenone-induced Parkinson's disease mice model.

Tarek K Motawi et al.

Molecular and cellular biochemistry, 465(1-2), 89-102 (2019-12-11)

Parkinson's disease (PD) is the second common age-related neurodegenerative disease. It is characterized by control loss of voluntary movements control, resting tremor, postural instability, bradykinesia, and rigidity. The aim of the present work is to evaluate curcumin, niacin, dopaminergic and

Adenosine-mediated enteric neuromuscular function is affected during herpes simplex virus type 1 infection of rat enteric nervous system.

Chiara Zoppellaro et al.

PloS one, 8(8), e72648-e72648 (2013-09-10)

Adenosine plays an important role in regulating intestinal motility and inflammatory processes. Previous studies in rodent models have demonstrated that adenosine metabolism and signalling are altered during chronic intestinal inflammatory diseases. However, the involvement of the adenosinergic system in the

The anti-tumor effect of A3 adenosine receptors is potentiated by pulsed electromagnetic fields in cultured neural cancer cells.

Fabrizio Vincenzi et al.

PloS one, 7(6), e39317-e39317 (2012-07-05)

A(3) adenosine receptors (ARs) play a pivotal role in the development of cancer and their activation is involved in the inhibition of tumor growth. The effects of pulsed electromagnetic fields (PEMFs) on cancer have been controversially discussed and the detailed

Number of Circulating CD 73-Expressing Lymphocytes Correlates With Survival After Cardiac Arrest.

Sergey Ryzhov et al.

Journal of the American Heart Association, 8(13), e010874-e010874 (2019-06-27)

Background Patients resuscitated from cardiac arrest ( CA ) have highly variable neurological, circulatory, and systemic ischemia-reperfusion injuries. After the initial hypoxic-ischemic insult, a cascade of immune and inflammatory responses develops and is often fatal. The role of the immune

Morphological control of mitochondria as the novel mechanism of Gastrodia elata in attenuating mutant huntingtin-induced protein aggregations.

Nai-Kuei Huang et al.

Phytomedicine : international journal of phytotherapy and phytopharmacology, 59, 152756-152756 (2019-04-21)

According to Compendium of Materia Medica, Gastrodia elata (GE) Blume as a top grade and frequently prescribed herbal medicine has been used in treating dizziness, headaches, and epilepsy, indicating a neuroprotective effect. Because GE is capable of suppressing a hyperactive

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