Anti-phospho-ZAP-70 (pTyr³¹⁵/pTyr³¹⁹) antibody produced in rabbit

ZAP-70 is a protein tyrosine kinase that is expressed in natural killer cells and T-lymphocytes. ZAP-70 interacts with the ζ chain of the T cell antigen receptor (TCR) and subsequently modulates cell signaling. Phosphorylation of Tyr³¹⁵ and Tyr³¹⁹ residues regulates TCR-mediated signal transduction . Anti-phospho-ZAP-70 pTyr³¹⁵/pTyr³¹⁹) antibody is specific for human ZAP-70. The product is expected to react with mouse ZAP-70 (as its 100% homologous to human ZAP-70), but has not been tested for it.

synthetic phosphopeptide derived from the region of human ZAP-70 that contains tyrosines 315 and 319.

Anti-phospho-ZAP-70 pTyr³¹⁵/pTyr³¹⁹) antibody is suitable for use in western blot (1:1,000 using Jurkat cells treated with H₂O₂ and immunoblot.

Solution in Dulbecco′s phosphate buffered saline (without Mg²⁺and Ca²⁺), pH 7.3, with 50% glycerol, 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.

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