Z0502
Zaleplon
≥98% (HPLC), solid
别名:
CL-284846, N-[3-(3-Cyanopyrazolo-[1,5-a]pyrimidin-7-yl)phenyl)-N-ethylacetamide
方案
≥98% (HPLC)
表单
solid
药品控制
USDEA Schedule IV; psychotrope (France); regulated under CDSA - not available from Sigma-Aldrich Canada
储存条件
desiccated
protect from light
颜色
white
溶解性
DMSO: ~20 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
CCN(C(C)=O)c1cccc(c1)-c2ccnc3c(cnn23)C#N
InChI
1S/C17H15N5O/c1-3-21(12(2)23)15-6-4-5-13(9-15)16-7-8-19-17-14(10-18)11-20-22(16)17/h4-9,11H,3H2,1-2H3
InChI key
HUNXMJYCHXQEGX-UHFFFAOYSA-N
基因信息
human ... GABRA1(2554), GABRB1(2560), GABRG2(2566)
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生化/生理作用
Zaleplon is a non-benzodiazepine agonist at the benzodiazepine site of the GABAA receptor; sedative; hypnotic.
特点和优势
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Warning
危险声明
危险分类
Repr. 2 - STOT SE 3
靶器官
Central nervous system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
K W Weitzel et al.
Clinical therapeutics, 22(11), 1254-1267 (2000-12-16)
Insomnia is the subjective complaint of poor sleep or an inadequate amount of sleep that adversely affects daily functioning. For the past 4 decades, treatment of insomnia has shifted away from the use of barbiturates toward the use of hypnotic
M Dooley et al.
Drugs, 60(2), 413-445 (2000-09-13)
Zaleplon is a pyrazolopyrimidine hypnotic agent which is indicated for the short term (2 to 4 weeks) management of insomnia. Zaleplon 5 and 10 mg at bedtime (usual recommended doses) significantly reduced sleep latency compared with placebo in clinical trials
Ane Birgitte Telén Andersen et al.
Pharmacoepidemiology and drug safety, 20(4), 378-385 (2011-01-25)
To estimate the degree of long-term use of zopiclone, zolpidem and zaleplon among Danes aged 65 and older and the association with sociodemographic factors and use of other drugs. Danish register-based study of 5000 men and 5000 women aged 65
W E Heydorn
Expert opinion on investigational drugs, 9(4), 841-858 (2000-11-04)
Zaleplon (N-[3-(3-cyanopyrazolo[1,5-a] pyrimidin-7-yl) phenyl]-N-ethyl acetamide) is a non-benzodiazepine recently introduced for clinical use. This agent is indicated for the short-term treatment of insomnia. Preclinical studies have shown that the benzodiazepines triazolam and Ro17-1812 can substitute for zaleplon in animals trained
Birgitta Norstedt Wikner et al.
Journal of clinical psychopharmacology, 31(3), 356-359 (2011-04-22)
Hypnotic benzodiazepine receptor agonists (HBRAs; zolpidem, zopiclone, and zaleplon) are used in the treatment of insomnia. Little is known about the safety of HBRAs during pregnancy. Data from the Swedish Medical Birth Registry from July 1, 1995, up to 2007
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