Z0877
佐替平
别名:
2-[(8-chlorodibenzo[b,f]-thiepin-10-yl)oxy]-N,N-dimethylethanamine
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关于此项目
经验公式（希尔记法）:
C18H18ClNOS
化学文摘社编号:
分子量:
331.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
assay
>98% (HPLC)
Quality Level
form
powder
color
white to off-white
solubility
DMSO: ≥20 mg/mL
originator
Astellas
storage temp.
room temp
SMILES string
CN(C)CCOC1=Cc2ccccc2Sc3ccc(Cl)cc13
InChI
1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3
InChI key
HDOZVRUNCMBHFH-UHFFFAOYSA-N
Application
Zotepine has been used as an anti-psychotic agent:
- in biophysical studies with serotonin 2A receptor (5-HT2AR)
- to study its effects on the inhibition of human organic cation transporter 1 (hOCT1)
- to study its protective effects on the human embryonic kidney (HEK cells)
Biochem/physiol Actions
Zotepine acts as an antagonist of dopamine D1, D2, and serotonin (5-HT2A/2C) receptors, and noradrenaline transporters. It shows therapeutic effects against schizophrenia and acute mania.
Zotepine is an atypical antipsychotic.
Features and Benefits
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Astellas. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
We offer many products related to dopamine receptors for your research needs.
We offer many products related to serotonin receptors for your research needs.
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相关内容
Kazuyoshi Nozaki et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 25(10), 1197-1201 (2009-10-14)
A simple, rapid, and sensitive on-line liquid chromatographic electrochemistry/electrospray/tandem mass spectrometry (LC-EC/ESI-MS/MS) method for the determination of zotepine in human serum was developed using a new generated-electrochemically fragment ion, and was validated. A recent novel technique of LC-EC/ESI-MS/MS that combines
Michael Riedel et al.
Expert opinion on drug safety, 9(4), 659-666 (2010-05-22)
Atypical antipsychotics have become the first-line treatment for patients suffering from schizophrenia in the industrialized world. Given the frequent necessity of a life-long enduring antipsychotic treatment, the compounds' safety profile is of great importance for patients and caregivers. Zotepine is
Britta Haenisch et al.
Naunyn-Schmiedeberg's archives of pharmacology, 385(10), 1017-1023 (2012-07-19)
Besides the three antidepressant-sensitive, Na(+)- and Cl(-)-dependent monoamine transporters, Na(+)-independent organic cation transporters (OCTs) are known to transport monoamines. However, little is known about the interactions of psychotropic drugs with human (h) OCTs. In the present study, a series of
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| Z0877-50MG | 04061832078397 |
| Z0877-10MG | 04061832078380 |