Z0877
佐替平
别名:
2-[(8-chlorodibenzo[b,f]-thiepin-10-yl)oxy]-N,N-dimethylethanamine
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关于此项目
经验公式（希尔记法）:
C18H18ClNOS
CAS Number:
分子量:
331.86
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
>98% (HPLC)
质量水平
表单
powder
颜色
white to off-white
溶解性
DMSO: ≥20 mg/mL
创始人
Astellas
储存温度
room temp
SMILES字符串
CN(C)CCOC1=Cc2ccccc2Sc3ccc(Cl)cc13
InChI
1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3
InChI key
HDOZVRUNCMBHFH-UHFFFAOYSA-N
应用
Zotepine has been used as an anti-psychotic agent:
- in biophysical studies with serotonin 2A receptor (5-HT2AR)
- to study its effects on the inhibition of human organic cation transporter 1 (hOCT1)
- to study its protective effects on the human embryonic kidney (HEK cells)
生化/生理作用
Zotepine acts as an antagonist of dopamine D1, D2, and serotonin (5-HT2A/2C) receptors, and noradrenaline transporters. It shows therapeutic effects against schizophrenia and acute mania.
Zotepine is an atypical antipsychotic.
特点和优势
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Astellas. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Hung-Yu Chan et al.
Psychiatry and clinical neurosciences, 64(2), 162-169 (2010-05-08)
Atypical antipsychotics are increasingly used in the management of acute mania. This study was conducted to investigate the efficacy and tolerability of zotepine compared to haloperidol in combination with a mood stabilizer (lithium or valproate) for treatment of acute mania.
Ben Green
Expert opinion on drug metabolism & toxicology, 5(2), 181-186 (2009-02-10)
Zotepine is a second generation antipsychotic drug, a substituted dibenzothiepine tricyclic molecule, with effects on dopamine, serotonin and noradrenaline receptors. This article reviews the relevant research studies on the drug based on a search of numerous medical databases for research
Michael Riedel et al.
Expert opinion on drug safety, 9(4), 659-666 (2010-05-22)
Atypical antipsychotics have become the first-line treatment for patients suffering from schizophrenia in the industrialized world. Given the frequent necessity of a life-long enduring antipsychotic treatment, the compounds' safety profile is of great importance for patients and caregivers. Zotepine is
S Yamamura et al.
British journal of pharmacology, 157(4), 656-665 (2009-04-18)
The atypical antipsychotic drug, zotepine, is effective in treatment of schizophrenia and acute mania, but the incidence of seizures during treatment is higher than with other antipsychotics. In addition, the mechanisms underlying the clinical actions of zotepine remain uncharacterized. The
Britta Haenisch et al.
Naunyn-Schmiedeberg's archives of pharmacology, 385(10), 1017-1023 (2012-07-19)
Besides the three antidepressant-sensitive, Na(+)- and Cl(-)-dependent monoamine transporters, Na(+)-independent organic cation transporters (OCTs) are known to transport monoamines. However, little is known about the interactions of psychotropic drugs with human (h) OCTs. In the present study, a series of
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