重组
expressed in baculovirus infected insect cells (Histidine tagged)
质量水平
方案
≥90% (SDS-PAGE)
表单
buffered aqueous glycerol solution
比活
≥150 U/mg
分子量
70 kDa
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... ZAP70(7535)
应用
Human ZAP-70 Tyrosine Kinase was used for mapping the phosphorylation sites on LAT (linker for activation of T cells) for investigating the mechanism of activation of signalling proteins in T cells.
生化/生理作用
ZAP-70 Tyrosine Kinase is a protein belongs to Syk family and is essential for T cell activation. It facilitates the upregulation of Fas ligand in activation-induced T cell apoptosis. Additionally, it also plays a pivotal role in LFA-1-dependent T Cell Migration.
ZAP-70 is protein tyrosine kinase of the Syk family that is localized exclusively to the cytosol of T cells and natural killer cells. It is required for T cell activation. It is activated by Lck-mediated phosphorylation of its tyrosine residues.
外形
Solution in 25 mM HEPES, pH 7.5, containing 150 mM NaCl, 0.5 mM DTT, and 50% glycerol.
其他说明
One unit will phosphorylate 1 nmol polyglutamic acid:tyrosine per min at 37 °C at pH 7.0.
储存分类代码
10 - Combustible liquids
WGK
WGK 1
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