Z2626
扎格雷酸 A 三钠盐
from microbial, ≥95% (HPLC), lyophilized powder, squalene synthase inhibitor
别名:
L-694,599, 鲨烯合成抑制剂
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关于此项目
经验公式（希尔记法）:
C35H43O14Na3
化学文摘社编号:
分子量:
756.68
UNSPSC Code:
12352106
NACRES:
NA.77
MDL number:
Application
萨拉哥（Zaragozic）酸 A 三钠盐可用作：
- 人类胚胎肾细胞的无血清培养基成分，在伤口刮擦测定中检测其对伤口愈合的作用
- 抑制剂，在基质细胞中抑制法尼基二磷酸法尼基转移酶1（FDFT1）或角鲨烯合成酶
- T细胞中的胆固醇合成抑制剂
Biochem/physiol Actions
哺乳动物，真菌和酿酒酵母角鲨烯合成酶的体内和体外有效抑制剂。角鲨烯合成酶是固醇合成中的第一个关键酶，催化焦磷酸法尼基还原缩合形成角鲨烯。作为角鲨烯合成酶抑制剂，扎格雷酸在灵长类动物中产生较低的血浆胆固醇水平。用扎格雷酸 A 处理大鼠导致肝脏低密度脂蛋白 (LDL) 受体 mRNA 水平升高。
Legal Information
根据 Merck & Co.,Inc.,Kenilworth,NJ 限制性授权许可生产和销售。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Isoprenoids increase bovine endometrial stromal cell tolerance to the cholesterol-dependent cytolysin from Trueperella pyogenes
Griffin S, et al.
Biology of Reproduction, 99(4), 749-760 (2018)
Topical mevastatin promotes wound healing by inhibiting the transcription factor c-Myc via the glucocorticoid receptor and the long non-coding RNA Gas5
Sawaya AP, et al.
Test, 293(4), 1439-1449 (2018)
OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling
So T, et al.
Journal of immunology (Baltimore, Md. : 1950), 186(6), 3547-3555 (2011)
Kaitlyn M Dykstra et al.
Oncotarget, 6(39), 41535-41549 (2015-11-26)
Multiple myeloma (MM) is characterized by the production of monoclonal protein (MP). We have shown previously that disruption of the isoprenoid biosynthetic pathway (IBP) causes a block in MP secretion through a disruption of Rab GTPase activity, leading to an
Y Ichinose et al.
Gene, 80(2), 315-323 (1989-08-15)
We have isolated cDNA clones encoding the mouse cytokeratin No. 19 (Ck 19) from an intestinal cDNA library using synthetic oligodeoxyribonucleotides as probes. We obtained four independent clones, which correspond to about 1.4-kb of ck19 cDNA. Nucleotide sequence analysis revealed
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Discover Bioactive Small Molecules for Lipid Signaling Research
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