Zardaverine

Name: Zardaverine
Brand: SIGMA

powder, ≥98% (HPLC)

别名:

6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₁₂H₁₀F₂N₂O₃

CAS Number:

101975-10-4

分子量:

268.22

MDL编号:

MFCD00867059

UNSPSC代码:

12352202

PubChem化学物质编号:

24278784

NACRES:

NA.77

Product Name

Zardaverine,

质量水平

200

SMILES字符串

COc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2

InChI

1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)

InChI key

HJMQDJPMQIHLPB-UHFFFAOYSA-N

基因信息

human ... PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE7A(5150)
rat ... Pde2a(81743), Pde4a(25638)

应用

Zardaverine has been used as a phosphodiesterase inhibitor:

to study its effects on human colonic epithelial cells
to study its effects on junctional proteins in Sertoli cells
to study its effects on phosphodiesterase 3 A (PDE3A) expression in various tumor cells

生化/生理作用

Selective inhibitor of phosphodiesterase III/IV (PDE3/4).

Zardaverine is a derivative of pyridazinone. It shows anti-tumor and anti-proliferative activity in varied cell lines. Zardaverine possesses broncho-dilatory activity and exhibits therapeutic effects against asthma.