Z3902
球姜酮
≥98% (HPLC), TRAIL-induced apoptosis potentiator, powder
别名:
(2E,6E,10E)-2,6,9,9-四甲基环十一烷-2,6,10-三烯-1-酮, 球姜酮（6CI，7CI）
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关于此项目
经验公式（希尔记法）:
C15H22O
化学文摘社编号:
分子量:
218.33
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
球姜酮, ≥98% (HPLC)
SMILES string
C\C1=C/CC(C)(C)\C=C\C(=O)\C(C)=C\CC1
InChI
1S/C15H22O/c1-12-6-5-7-13(2)14(16)9-11-15(3,4)10-8-12/h7-9,11H,5-6,10H2,1-4H3/b11-9+,12-8+,13-7+
InChI key
GIHNTRQPEMKFKO-SKTNYSRSSA-N
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
Quality Level
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相关类别
General description
花姜酮是从红球姜根茎中提取的单环倍半萜化合物。它具有抗微生物、镇痛、抗动脉粥样硬化、肝保护和抗氧化作用。花姜酮还具有抗炎和抗癌作用。
Application
花姜酮已用于：
- 液相色谱-质谱联用(LC-MS-MS)
- 研究其潜在的预防能力
- 治疗食管鳞状细胞癌(ESCC)
Biochem/physiol Actions
TRAIL 诱导凋亡增效剂；DR4 和 DR5 诱导剂
Zerumbone 是一种 TRAIL 诱导的细胞凋亡增强剂。它通过上调 DR4 和 DR5 的表达及下调 cFLIP 而加强 TRAIL 诱导的细胞凋亡。Zerumbone 对正常人内皮细胞和皮肤成纤维细胞几乎无细胞毒性作用。Zerumbone 是从姜属植物 Zingiber zerumbet Smith（野生姜）中分离得到的一种倍半萜烯。
signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Eltayeb E M Eid et al.
Journal of mass spectrometry : JMS, 46(8), 772-781 (2011-08-13)
A rapid, sensitive, specific and selective LC-MS/MS method for the determination of zerumbone (ZER) in human plasma using 2,4-diamino-6-(4-methoxyphenyl)-1,3,5-triazine (DMTZ) as an internal standard (IS) has been developed and validated. ZER was chromatographed on C8 column using a mobile phase
Anuradha Sehrawat et al.
Breast cancer research and treatment, 136(2), 429-441 (2012-10-12)
The present study was undertaken to determine the anticancer efficacy of zerumbone (ZER), a sesquiterpene from subtropical ginger, against human breast cancer cells in vitro and in vivo. ZER treatment caused a dose-dependent decrease in viability of MCF-7 and MDA-MB-231
Behnam Kamalidehghan et al.
Iranian biomedical journal, 16(4), 226-226 (2012-11-28)
Zerumbone is a cytotoxic compound isolated from the herbal plant, Zingiber zerumbet Smith, which exhibits antitumor activity [1-2], anti-inflammatory effects and possesses anti-proliferative potentials in a variety of cell lines [3-4]. DNA fragmentation indicates an early event of apoptosis leading
John H Beattie et al.
Molecular nutrition & food research, 55 Suppl 2, S203-S213 (2011-10-05)
Natural dietary anti-obesogenic phytochemicals may help combat the rising global incidence of obesity. We aimed to identify key hepatic pathways targeted by anti-obsogenic ginger phytochemicals fed to mice. Weaning mice were fed a high-fat diet containing 6-gingerol (HFG), zerumbone (HFZ)
Siddig Ibrahim Abdelwahab et al.
International immunopharmacology, 12(4), 594-602 (2012-02-15)
Interleukin-6 is one of the factors affecting sensitivity to cytotoxic agents. Therefore, the current study was designed to investigate the role of IL-6 and IL6 receptors in the cytotoxic effects of zerumbone in ovarian and cervical cancer cell lines (Caov-3
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Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
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