产品名称
Astec® CHIROBIOTIC® T 手性 HPLC 色谱柱, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
物料
stainless steel column
质量水平
Agency
suitable for USP L63
描述
HPLC column
产品线
Astec®
包装
pkg of 1 ea
制造商/商品名称
Astec®
参数
0-45 °C temperature
241 bar pressure (3500 psi)
技术
HPLC: suitable
LC/MS: suitable
长度 × 内径
15 cm × 4.6 mm
基质
High-purity silica gel particle platform
fully porous particle
基质活性基团
teicoplanin glycopeptide phase
粒径
5 μm
孔径
100 Å
工作pH范围
3.8-6.8
分离技术
chiral
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一般描述
CHIROBIOTIC® T和T2具有替考拉宁作为手性选择剂。它们对许多类别的分子可提供独特的选择性，特别是未衍生化的α, β, γ以及环氨基酸、N-衍生氨基酸、羟基-羧基酸，酸性化合物包括羧基酸及酚、小肽、中性芳香族分析物及环状芳香族和脂肪族胺。通常在手性的冠醚或配体交换型CSP上获得的分离也可能发生在CHIROBIOTIC®T和T2上，但是是在大为简单的移动相如水-乙醇中。此外，所有已知的β-阻滞剂（氨醇）以及二氢香豆素都已被分解。CHIROBIOTIC® T和T2在它们的键化学和支持颗粒的孔径上存在差别，分别赋予了它们不同的选择和制备能力。
CHIROBIOTIC FAQ
CHIROBIOTIC 参考书目
Chiral产品文献
- 键合相：替考拉宁
- 操作pH范围：3.8 - 6.8
- 粒子直径：5、10或16 μm
- 孔径：100 Å (CHIROBIOTIC® T)或200 Å (CHIROBIOTIC® T2)
CHIROBIOTIC FAQ
CHIROBIOTIC 参考书目
Chiral产品文献
应用
- Chiral liquid chromatography-mass spectrometry (LC-MS/MS) method development for the detection of salbutamol in urine samples.：通过手性液相色谱-质谱技术检测尿中的沙丁胺醇，说明柱子可用于灵敏的生物医学试验( Chan et al., 2016)。
- High-performance liquid chromatographic enantioseparation of 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids on macrocyclic glycopeptide-based phases.：研究表明柱子可用于特定环状氨基酸的手性分离，证明它的多用性和手性分离作用( Berkecz et al., 2009)。
法律信息
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
Balázs Visegrády et al.
Journal of biochemical and biophysical methods, 53(1-3), 15-24 (2002-10-31)
This contribution deals with comparative studies on the chiral separation of thiazide diuretics using cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD-RH), cellulose tris(4-methylbenzoate) (Chiralcel OJ-R) and teicoplanin (Chirobiotic T) phases. All columns showed good chiral recognition ability for this class of compounds. Out
Zahid Ali et al.
Journal of chromatography. A, 1052(1-2), 199-204 (2004-11-06)
The solvation parameter model is used to characterize the retention properties of a 3-aminopropylsiloxane-bonded (Alltima amino), three 3-cyanopropylsiloxane-bonded (Ultrasphere CN, Ultremex-CN and Zorbax SB-CN), a spacer bonded propanediol (LiChrospher DIOL) and a multifunctional macrocyclic glycopeptide (Chirobiotic T) silica-based stationary phases
B Mistry et al.
Journal of chromatography. B, Biomedical sciences and applications, 758(2), 153-161 (2001-08-07)
A sensitive and stereoselective high-performance liquid chromatographic assay for the determination of the enantiomers of metoprolol (R- and S-) and the diastereoisomers of alpha-hydroxymetoprolol (IIA, IIB) in plasma is reported. Chromatography involved direct separation of enantiomers using a Chirobiotic T
P Jander et al.
Journal of chromatography. A, 919(1), 67-77 (2001-07-19)
The retention behaviour of the enantiomers of underivatized phenylglycine was studied on a Chirobiotic T column packed with amphoteric glycopeptide teicoplanin covalently bonded to the surface of silica gel. The retention and the selectivity of separation of the enantiomers increase
Berit P Jensen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 865(1-2), 48-54 (2008-03-07)
A stereoselective liquid chromatography-tandem mass spectrometry assay was developed and validated for quantification of S- and R-metoprolol at concentrations of 0.5-50 microg/L in human plasma. Metoprolol was extracted from plasma by liquid-liquid extraction with ethyl acetate (82% recovery). Chromatographic separation
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