产品名称
Astec® CHIROBIOTIC® R手性HPLC柱, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
material
stainless steel column
description
HPLC column
product line
Astec®
packaging
pkg of 1 ea
manufacturer/tradename
Astec®
parameter
0-45 °C temperature
241 bar pressure (3500 psi)
technique(s)
HPLC: suitable
LC/MS: suitable
L × I.D.
25 cm × 4.6 mm
matrix
high-purity silica gel particle platform
fully porous particle
matrix active group
ristocetin A glycopeptide phase
particle size
5 μm
pore size
100 Å
operating pH range
3.5-6.8
separation technique
chiral
Quality Level
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Application
- 乳酸异构体的灵敏分析：Astec® CHIROBIOTIC® R手性HPLC色谱柱在Henry H等的研究中发挥了重要作用，它用于通过高效液相色谱-串联质谱法灵敏测定尿液中的D-乳酸和L-乳酸。该方法对临床诊断极具意义，因柱子可分离其它方法难以区分的相似化合物(Henry H et al., 2012)。
- 环戊烷羧酸和环己烷羧酸的手性分离：Berkecz R等也采用该柱子通过高效液相色谱法手性分离了多种复杂的2-氨基单-和二羟基环戊烷羧酸和2-氨基二羟基环己烷羧酸。体现柱子的多用性以及分离密切相关手性酸的作用，对生化研究和药品开发极具意义(Berkecz R et al., 2009)。
General description
CHIROBIOTIC® R色谱柱以高纯硅胶为基质并以共价键键合了瑞斯托菌素A糖肽，已表现出适用于分离阴离子化合物对映体的特殊性能。CHIROBIOTIC ®R的选择性与有机改性剂密切相关，极其有利于醇类流动相。
CHIROBIOTIC FAQ
CHIROBIOTIC参考书目
Chiral产品文献
- 键合相：瑞斯西丁A
- pH适用范围：3.5 - 6.8
- 粒子直径：5、10或16 μm
- 孔径：100 Å
CHIROBIOTIC FAQ
CHIROBIOTIC参考书目
Chiral产品文献
Legal Information
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
Enzyme-catalyzed synthesis of (R)- and (S)-3-hydroxy-3-(10-alkyl-10H-phenothiazin-3-yl)propanoic acids
Brem, Jurgen, et al.
Tetrahedron Asymmetry, 21 (3), 365-373 (2010)
P Dehouck et al.
Journal of chromatography. A, 1010(1), 63-74 (2003-09-25)
Erythromycin is a mixture of macrolide antibiotics produced by Saccharopolyspora erythreas during fermentation. A new method for the analysis of erythromycin by liquid chromatography has previously been developed. It makes use of an Astec C18 polymeric column. After validation in
H Henry et al.
Biomedical chromatography : BMC, 26(4), 425-428 (2011-08-16)
D-lactic acid in urine originates mainly from bacterial production in the intestinal tract. Increased D-lactate excretion as observed in patients affected by short bowel syndrome or necrotizing enterocolitis reflects D-lactic overproduction. Therefore, there is a need for a reliable and
Sébastien Canneaux et al.
The journal of physical chemistry. A, 114(34), 9270-9288 (2010-08-03)
The rate constants of the reactions of iodine atoms with H(2), H(2)O, HI, and OH have been estimated using 39, 21, 13, and 39 different levels of theory, respectively, and have been compared to the available literature values over the
B DeCruze et al.
Clinical oncology (Royal College of Radiologists (Great Britain)), 11(4), 252-254 (1999-09-04)
Poor prognosis (poorly differentiated and/or deep myometrial invasion) Stage I endometrial cancer can have a relapse rate as high as 50%. Traditionally, most clinical oncologists treat these patients with external beam radiotherapy after surgery but there is no evidence to
实验方案
Rapid, simple, reproducible chiral separation and quantification of L- and D-lactic acid enantiomers using Supelco’s Astec CHIROBIOTIC® R chiral column and tandem MS.
We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.
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