15020AST
Astec® CHIROBIOTIC® V2 Chiral (5 μm) HPLC Columns
L × I.D. 25 cm × 2.1 mm, HPLC Column
别名:
TM=["Astec"] TM=["CHIROBIOTIC"] V2手性色谱柱
产品名称
Astec® CHIROBIOTIC® V2手性HPLC色谱柱, 5 μm particle size, L × I.D. 25 cm × 2.1 mm
material
stainless steel column
agency
suitable for USP L88
description
HPLC column
product line
Astec®
packaging
pkg of 1 ea
manufacturer/tradename
Astec®
parameter
0-45 °C temperature
241 bar pressure (3500 psi)
technique(s)
HPLC: suitable
LC/MS: suitable
L × I.D.
25 cm × 2.1 mm
matrix
High-purity silica gel particle platform
fully porous particle
matrix active group
vancomycin phase
particle size
5 μm
pore size
200 Å
operating pH range
3.5-7.0
separation technique
chiral
Quality Level
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Application
- Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-threo-methylphenidate, d,l-threo-ethylphenidate and d,l-threo-ritalinic acid in rat plasma and its application to pharmacokinetic study.：采用Astec® CHIROBIOTIC® V2手性HPLC色谱柱开发和验证一种UFLC-MS/MS方法，对映选择性测定大鼠血浆中的各种哌甲酯和利太林酸(ritalinic acid)对映体。柱子在药动学研究中的应用体现其生化研究作用，特别是用于手性药物分子分析(Zhang et al., 2016)。
- New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase.：采用Astec® CHIROBIOTIC® V2手性HPLC色谱柱手性分离和测定华法林对映体。说明柱子可用于药物分析，特别已在手性药物对映体研究中发挥作用(Malakova et al., 2009)。
General description
中性分子、酰胺、酸、酯和胺对这些基于万古霉素的CSP显示出相当大的对映选择性。在CHIROBIOTIC® V的极性离子模式下，分离出各种各样的仲胺和叔胺分子。CHIROBIOTIC® V已经表现出蛋白质固定相的许多分离特性，但同时具有出色的稳定性和更高的样品容量。一些尚未报道在任何其他手性固定相上得到分离的手性分析物被分离出来。CHIROBIOTIC® V和V2的区别在于键合化学性质与载体颗粒的孔径不同，这赋予它们不同的选择性和制备能力。
CHIROBIOTIC FAQ
CHIROBIOTIC参考书目
Chiral产品文献
- 键合相：万古霉素
- 工作pH范围：3.5 - 7.0
- 粒径：5、10或16 μm
- 孔径：100Å（CHIROBIOTIC® V）或200Å（CHIROBIOTIC® V2）
CHIROBIOTIC FAQ
CHIROBIOTIC参考书目
Chiral产品文献
Legal Information
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
Chromatography Liquid Chiral Separations
Xiao, T.L., et al.
Encyclopedia of Separation Science, 1-15 (2000)
Enantioselective and sensitive determination of carvedilol in human plasma using chiral stationary-phase column and reverse-phase liquid chromatography with tandem mass spectrometry
Jiang, Juanjuan, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 960, 92-97 (2014)
Validation of a chiral liquid chromatography?tandem mass spectrometry method for the determination of pantoprazole in dog plasma
Chen, Meixia, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 906, 85-90 (2012)
Doris Frühauf et al.
Journal of chromatography. A, 1269, 242-254 (2012-10-30)
A sub-minute enantioselective normal phase high performance liquid chromatographic (HPLC) method for the analysis of a chiral precursor molecule employed frequently in folic acid syntheses was developed, optimized and successfully validated according to ICH-guidelines. It could be shown that ultra-high
New chemo-enzymatic approaches for the synthesis of (R)- and (S)-bufuralol
Nagy, Botond, et al.
Tetrahedron Asymmetry, 25 (18-19), 1316-1322 (2014)
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