Flutolanil

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ. Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate. Download your certificate at: http://www.sigma-aldrich.com

Flutolanil is a systemic amide fungicide with curative and protective action, belonging to the chemical class of phenylbenzamide. It is widely used in crops, fruits, vegetables, and some ornamentals to control diseases caused by basidiomycetes. It is effective against rice sheath blight, wheat sharp eyespot, potato stem canker, black scurf, peanut stem rot, tall fescue brown patch caused by Rhizoctonia, and other plant diseases caused by Corticium, Typhula, and Gymnosporangium. Flutolanil acts by inhibiting the synthesis of succinate dehydrogenase (SDH), in mitochondrial complex II, disrupting the Krebs cycle and the mitochondrial electron transport chain.

According to Regulation (EC) 1107/2009 (repealing 91/414/EEC) flutolanil is approved for use in European Union (EU). The maximum residue level (MRL) for flutolanil, following Reg. (EU) 2021/2202, is set from 0.01 mg/kg to 2 mg/kg for products of plant and animal origin.

The certified reference material (CRM) is intended to be used as a calibrant for chromatography and other analytical techniques. The flutolanil CRM may also find following uses:

• Examine the reproductive endpoints on the gonad endocrine system of the parental zebrafish after chronic exposure to different concentrations of flutolanil for 60 days
• Spectroscopic analysis of acetamiprid, flutolanil, and etofenprox residues extracted from tomato fruits
• Development and validation of two robust chromatographic methods for estimation of tomatoes specific acetamiprid, flutolanil, and etofenprox residues on fruits before food processing and serving
• To investigate the developmental toxicity and the potential mechanism of thyroid endocrine disruption induced by flutolanil in zebrafish embryos based on ¹H NMR metabolomics analysis
• To develop a sensitive LC-MS/MS analytical method for the determination of residual flutolanil and its principal metabolites and conjugates, in livestock and seafood products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany