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Merck
CN

442641

盐酸美沙吡林

analytical standard

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关于此项目

化学文摘社编号:
135-23-9
UNSPSC Code:
12352200
PubChem Substance ID:
24867939
EC Number:
205-184-8
MDL number:
MFCD00050665
NACRES:
NA.24

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format

neat

InChI key

BONORRGKLJBGRV-UHFFFAOYSA-N

InChI

1S/C14H19N3S.ClH/c1-16(2)9-10-17(12-13-6-5-11-18-13)14-7-3-4-8-15-14;/h3-8,11H,9-10,12H2,1-2H3;1H

SMILES string

CN(C)CCN(CC1=CC=CS1)C2=NC=CC=C2.Cl

grade

analytical standard

CofA

current certificate can be downloaded

packaging

ampule of 1000 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

clinical testing

storage temp.

2-30°C

Quality Level

100

Gene Information

human ... HRH1(3269)

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相关类别

General description

Methapyrilene is an H1-receptor antihistamine that is known to cause periportal hepatic necrosis following acute high dose administration to the rat subjects in in vitro studies carried out for the identification of mutagens and/or carcinogens.

Application

Methapyrilene HCl may be used as an analytical reference standard for the determination of the analyte in animal feed, human urine and wastewater by high-performance liquid chromatography (HPLC) and gas chromatography (GC) techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
LRAE1513
LRAD5761
LRAC8592
LC23583V
LC22072V

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Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation.
Ratra GS, et al.
Chemico-Biological Interactions, 129(3), 279-295 (2000)
Trace analysis of the antihistamines methapyrilene hydrochloride, pyrilamine maleate and triprolidine hydrochloride monohydrate in animal feed, human urine and wastewater by high-performance liquid chromatography and gas chromatography with nitrogen-phosphorus detection.
Thompson Jr HC and Holder CL
Journal of Chromatography A, 283(3), 251-264 (1984)

商品

LC-MS Analysis of Serum for a Wide Analyte Range Using a Novel HLB SPE Phase

Analysis of 20 pharmaceutical compounds in calf serum using Supel™ Swift HLB SPE cartridge for cleanup and LC-MS determination and another commercially available HLB cartridge for comparison.

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