47782
D-α-生育酚琥珀酸酯
analytical standard
别名:
维生素 E 琥珀酸酯
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关于此项目
经验公式（希尔记法）:
C33H54O5
化学文摘社编号:
分子量:
530.78
EC Number:
224-403-8
UNSPSC Code:
12164500
PubChem Substance ID:
Beilstein/REAXYS Number:
4038233
MDL number:
NACRES:
NA.24
产品名称
D-α-生育酚琥珀酸酯, analytical standard
InChI
1S/C33H54O5/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-20-33(8)21-19-28-27(7)31(25(5)26(6)32(28)38-33)37-30(36)18-17-29(34)35/h22-24H,9-21H2,1-8H3,(H,34,35)/t23-,24-,33-/m1/s1
InChI key
IELOKBJPULMYRW-NJQVLOCASA-N
SMILES string
CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(=O)CCC(O)=O)c(C)c(C)c2O1
grade
analytical standard
CofA
current certificate can be downloaded
feature
standard type fat soluble vitamin
packaging
ampule of 100 mg
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
vitamins, nutraceuticals, and natural products
format
neat
storage temp.
2-8°C
Quality Level
Application
有关合适的仪器技术的更多信息，请参阅产品的分析证书。如需进一步支持，请联系技术服务。
General description
D-α-生育酚琥珀酸酯是一种强效的生育酚抗氧化剂，具有抗肿瘤活性，并可抑制结肠癌肝转移。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Vitamin E succinate inhibits colon cancer liver metastases
Barnett TK, et al.
The Journal of Surgical Research, 106(2), 292-298 (2002)
Dasheng Wang et al.
Journal of medicinal chemistry, 52(18), 5642-5648 (2009-08-28)
This study is aimed at the pharmacological exploitation of alpha-tocopheryl succinate (1) to develop potent antiadhesion agents. Considering the structural cooperativity between the phytyl chain and the carboxylic terminus in determining the antiadhesion activity, our structural optimization led to compound
Vitamin E succinate promotes breast cancer tumor dormancy
Malafa PM, et al.
The Journal of Surgical Research, 93(1), 163-170 (2000)
Pengfei Xu et al.
Biomaterials, 35(26), 7574-7587 (2014-06-06)
Metastasis is one of the major obstacles for the successful therapy of breast cancer. Although increased candidate drugs targeting cancer metastasis are tested, their clinical translation is limited by either serve toxicity or low efficacy. In present work, a nano-drug
Yanyun Xu et al.
International journal of pharmaceutics, 495(2), 792-797 (2015-09-28)
Our recent publication showed that VES-dFdC nanocapsules in pure water could be obtained via the self-assembling of VES-dFdC prodrug synthesized by coupling gemcitabine (dFdC) with vitamin E succinate (VES). To prepare the intravenous injection nanoformulation, we present here a novel
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