产品名称
2-(2-吡啶基)乙基硅胶, bed wt 100 mg, volume 1 mL, pk of 108
composition
bed wt, 100 mg
packaging
pk of 108
technique(s)
solid phase extraction (SPE): suitable
volume
1 mL
matrix active group
WAX phase
Quality Level
application(s)
food and beverages
separation technique
ion exchange
General description
保留机理：阴离子交换
样品基质相容性：有机或含水溶液
样品基质相容性：有机或含水溶液
- 极其适用于萃取在所有 pH 水平保持带电荷的强碱性化合物的弱阴离子交换剂
- 与诸如 pKa 为 9-10 的 -NH2 （丙胺基）等常规的弱阴离子交换固相萃取相不同，需要 pH ≤ 7 的环境来质子化或离子化固定相，以便于分析物的保留。通常通过增大 pH 至 11 实现固相萃取相的中和来进行洗脱。
- 2-(2-吡啶基)-乙基硅胶的 pKa 约为 6。因此可在 pH ≥ 7 时进行洗脱。该特性对于萃取在高 pH 环境下不稳定（如水解）的分析物非常重要，而当使用传统的弱阴离子交换剂进行洗脱时通常需要这样的高 pH 环境。
- 它是从组织中萃取酰基-辅酶 A 酯的理想选择。
- 需要更多的信息请参阅：Minkler, P.E., Kerner, J., Ingalls, S.T., Hoppel, C.L., Novel isolation procedure for short-, medium-, and long-chain acyl-coenzyme A esters from tissue, Analytical Biochemistry 376 (2008) 275–276
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Andrea Arias-Alvarado et al.
Analytical biochemistry, 615, 114067-114067 (2020-12-20)
Cellular availability of acetyl-CoA, a central intermediate of metabolism, regulates histone acetylation. The impact of a high-fat diet (HFD) on the turnover rates of acetyl-CoA and acetylated histones is unknown. We developed a method for simultaneous measurement of acetyl-CoA and
商品
SPE retention mechanism in this case is based on the electrostatic attraction of charged functional groups of the analyte(s) to oppositely charged functional groups on the sorbent.
实验方案
Normal-phase SPE separates analytes based on polar interaction with sorbents in diverse sample matrices.
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