产品名称
Discovery® HS C18 高效液相色谱柱, 3 μm particle size, L × I.D. 7.5 cm × 4.6 mm
物料
stainless steel column
质量水平
Agency
suitable for USP L1
产品线
Discovery®
特点
endcapped
制造商/商品名称
Discovery®
包装
1 ea of
标记范围
20% Carbon loading
参数
≤70 °C temp. range
400 bar pressure (5801 psi)
技术
HPLC: suitable
LC/MS: suitable
长度 × 内径
7.5 cm × 4.6 mm
表面积
300 m2/g
表面覆盖度
3.2 μmol/m2
杂质
<10 ppm metals
基质
silica gel, high purity, spherical particle platform
fully porous particle
基质活性基团
C18 (octadecyl) phase
粒径
3 μm
孔径
120 Å
工作pH范围
2-8
应用
food and beverages
分离技术
reversed phase
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一般描述
Discovery® HS C18 HPLC柱（L × 内径7.5 cm × 4.6 mm）在酸性和碱性条件下一般比较稳定。
应用
- 一种稳定性指示RP-HPLC方法，用于渗透性研究中以纳米制剂应用的COVID-19药物莫努匹韦的测定。：本研究展示了使用Discovery® HS C18 HPLC色谱柱开发分析莫努匹韦的稳健HPLC方法，展示了其在当前疫情相关药物研究中的重要性（Recber et al., 2022）。
- 一种新的RP-HPLC方法，作为优化样品制备程序的辅助工具，用于追踪不同亲水性PPCP。：重点介绍了Discovery® HS C18 HPLC色谱柱在环境监测中的适用性，特别是在制药和个人护理产品方面，改善了环境安全分析方法（Portillo-Castillo et al., 2021）。
- HPLC-UV法分析血浆中的特立齐酮及其在耐药结核病患者药代动力学研究中的应用。：本研究使用Discovery® HS C18 HPLC色谱柱评估患者血浆中的特立齐酮水平，为耐药结核病的治疗提供重要见解（Mulubwa and Mugabo, 2018）。
- 从药代动力学、生物医学和药物监测治疗研究的角度优化定量检测血浆和尿液样品中阿霉素的LC方法。：介绍了使用Discovery® HS C18 HPLC色谱柱优化强效化疗药物阿霉素的液相色谱检测方法，强调了其在治疗药物监测中的作用（Maliszewska et al., 2018）。
- 通用HPLC-UV法测定转运研究、大鼠胎盘灌注和胎盘裂解物中的依非韦伦。：展示了Discovery® HS C18 HPLC色谱柱在研究依非韦伦在胎盘中的渗透性和转运方面的应用，提供了有价值的药理学见解（Zelena et al., 2017）。
特点和优势
- 稳定性好、低流失，适用于 LC-MS 分析
- 提供有适用于分析型到制备型的各种规格
- 稳定性好，以确保柱与柱和批与批之间之间优良的重现性
- 更强的疏水性能够更好地分离难分析化合物
法律信息
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
13 - Non Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Fazli Khuda et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 944, 114-122 (2013-12-10)
A simple, specific, precise and rapid RP-HPLC-UV method was developed for simultaneous determination of lumefantrine and its metabolite desbutyl lumefantrine in human plasma. Experimental parameters were optimized and the method was validated according to standard guidelines. The method showed adequate
Abad Khan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(28), 2782-2788 (2010-09-11)
A rapid, inexpensive, sensitive and specific HPLC-ECD method for the determination of lipoic acid in human plasma was developed and validated over the linearity range of 0.001-10μg/ml using naproxen sodium as an internal standard (IS). Extraction of lipoic acid and
Lucie Zelena et al.
Journal of pharmaceutical and biomedical analysis, 137, 70-77 (2017-01-17)
Efavirenz is an antiretroviral drug used in the treatment of HIV-positive patients. A simple, fast and sensitive high-performance liquid chromatography (HPLC) method was developed in order to determine efavirenz in three types of samples provided from pharmacokinetic studies. The analysis
Steinar Uran et al.
Journal of pharmaceutical and biomedical analysis, 44(4), 947-954 (2007-05-08)
Injection of hyperpolarized (13)C-labelled pyruvate ((13)C pyruvate) is under evaluation as an agent for medical metabolic imaging by measuring formation of (13)C lactate using magnetic resonance spectroscopy of the (13)C nuclei. A quantitative method for analysis of these (13)C-labelled substances
Abad Khan et al.
Talanta, 84(3), 789-801 (2011-04-13)
A new, simple, economical and validated high-performance liquid chromatography linked with electrochemical detector (HPLC-ECD) method has been developed and optimized for different experimental parameters to analyze the most common monothiols and disulfide (cystine, cysteine, homocysteine, methionine, reduced (GSH) and oxidized
相关内容
HPLC DiscoveryBIO HS C18 products. Available in 3µm, 5µm and 10µm particle sizes.
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