产品名称
Discovery® DCS-Si 固相萃取 96 孔板, bed wt. 50 mg/well, pk of 1
material
PE frit (20 μm)
polypropylene hardware
composition
bed wt., 50 mg/well
packaging
pk of 1
technique(s)
solid phase extraction (SPE): suitable
surface area
480 m2/g
matrix
silica gel base material (irregularly shaped, acid washed)
matrix active group
silica bonding
particle size
50 μm
pore size
70 Å pore size
application(s)
food and beverages
separation technique
normal phase
Quality Level
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General description
助留机理：正相
样品基质相容性：有机溶剂、油类和脂类
样品基质相容性：有机溶剂、油类和脂类
- 未键合的酸洗硅胶吸附剂，是正相固相萃取以及其他改进型闪蒸技术的理想选择
- 通常用于通过不断增大的溶液的极性，采用连续洗脱来分离或移除结构相似的分子
- 可使用的极性最大的正相吸附剂
- 极好的柱容量用于纯化组合化学反应的溶液相，从反应副产物和过剩试剂中移除目标分子
- 可提供布氏漏斗构型，便于放大
Application
- High-Throughput Mass Spectrometry for Biopharma: Utilizes the Discovery DSC-Si SPE 96-well plate for rapid and accurate biomolecule characterization, demonstrating its critical role in high-throughput analytical setups, enhancing productivity in biopharmaceutical analysis (Campuzano et al., 2022).
- Towards a Point-of-Care Diagnostic Platform for Multiplex Sensing: Highlights the application of Discovery DSC-Si SPE 96-well plates in developing advanced diagnostic platforms, specifically for detecting mild traumatic brain injury biomarkers, showcasing the plate′s versatility and reliability in clinical settings (Jović et al., 2022).
- Determination of Crizotinib in Plasma by LC-ESI-MS/MS: Demonstrates the use of Discovery DSC-Si SPE 96-well plates in pharmacokinetic studies, providing robust and efficient sample preparation methods for therapeutic drug monitoring and clinical research (Roberts et al., 2014).
- High-throughput Mass Spectrometric Cytochrome P450 Inhibition Screening: Applies the Discovery DSC-Si SPE 96-well plate in drug metabolism studies, specifically in the screening of cytochrome P450 enzyme inhibitors, which is crucial for predicting drug-drug interactions in drug development (Lim et al., 2013).
- Development of a High-Throughput SPE/MS Method for Cytochrome P450 Inhibition: Uses the Discovery DSC-Si SPE 96-well plate to enhance throughput in the pharmacological screening of drug candidates, underscoring its importance in the early stages of drug discovery to assess potential toxicities (Lim et al., 2010).
Legal Information
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
相关内容
固相萃取(SPE)是一种用在色谱分析（如 HPLC、GC、TLC 色谱）前快速、选择性制备和纯化样品的技术，主要用于置换样品基质、浓缩分析物、去除干扰成分和污染物，以改善数据结果、保护分析色谱柱。
Solid phase extraction purifies samples for chromatographic analysis, improving data quality and protecting analytical columns.
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