产品名称
Cyano HPLC 色谱柱 ®, 5 μm particle size, L × I.D. 25 cm × 4 mm
物料
stainless steel column
质量水平
Agency
suitable for USP L10
产品线
Discovery®
特点
endcapped
制造商/商品名称
Discovery®
包装
1 ea of
标记范围
4.5% Carbon loading
参数
≤70 °C temp. range
400 bar pressure (5801 psi)
技术
HPLC: suitable
LC/MS: suitable
长度 × 内径
25 cm × 4 mm
表面积
200 m2/g
表面覆盖度
3.5 μmol/m2
杂质
<10 ppm metals
基质
silica gel, high purity, spherical base material
fully porous particle
基质活性基团
cyano phase
粒径
5 μm
孔径
180 Å
工作pH范围
2-8
应用
food and beverages
分离技术
hydrophilic interaction (HILIC)
normal phase
reversed phase
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特点和优势
- 低疏水性可实现对疏水性化合物的快速洗脱
- 分析强碱性化合物具有优良的峰形和保留性能
- 对极性化合物具有较强的保留能力
- 独特的选择性
- 保留时间显著小于 C18 柱（通常流动相中所需有机相比例更低）
- 稳定性好、低流失，适用于 LC-MS 分析
- 与高含水量的流动相兼容
法律信息
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
Graciela B Arhancet et al.
Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships
Srdan Verstovsek et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(3), 788-796 (2008-02-05)
The discovery of an activating somatic mutation in codon 617 of the gene encoding the Janus kinase (JAK)-2 (JAK2 V617F) in patients with myeloproliferative disorders has opened new avenues for the development of targeted therapies for these malignancies. However, no
K Umekawa et al.
Japanese journal of pharmacology, 84(1), 7-15 (2000-10-24)
We describe the pharmacological characteristics of SM-19712 (4-chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl] benzenesulfonamide, monosodium salt). SM-19712 inhibited endothelin converting enzyme (ECE) solubilized from rat lung microsomes with an IC50 value of 42 nM and, at 10 - 100 microM, had no effect on other
Christophe Morisseau et al.
Analytical biochemistry, 414(1), 154-162 (2011-03-05)
The microsomal epoxide hydrolase (mEH) plays a significant role in the metabolism of numerous xenobiotics. In addition, it has a potential role in sexual development and bile acid transport, and it is associated with a number of diseases such as
T A Verdoorn et al.
European journal of pharmacology, 269(1), 43-49 (1994-09-15)
The diversity of neuronal glutamate receptors continues to increase with the discovery of multiple subunits and subunit families. The significance of this potential receptor heterogeneity is unknown because pharmacological tools that could clearly distinguish between different structural isoforms have not
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