material
fused silica
description
GC capillary column
analyte chemical class(es)
alcohols, amino acids, amphetamines, ketones, terpenes
packaging
pkg of 1 ea
parameter
-10-180 °C temperature (isothermal or programmed)
Beta value
500
df
0.12 μm
technique(s)
gas chromatography (GC): suitable
L × I.D.
30 m × 0.25 mm
matrix active group
Chiral, non-bonded; 2,6-di-O-pentyl-3-trifluoroacetyl derivative of γ-cyclodextrin phase
application(s)
agriculture
chemicals and industrial polymers
cleaning products
clinical
cosmetics
environmental
flavors and fragrances
food and beverages
forensics and toxicology
life science and biopharma
personal care
pharmaceutical (small molecule)
column type
capillary chiral
separation technique
chiral
General description
Astec® CHIRALDEX G-TA 是第 1 组 CSP（表面相互作用，复合衍生物）的首选。该阶段已被证明是制药行业最广泛选择的阶段，特别是在临床试验的各个阶段中手性中间体和药物研究的分析。在没有包含机制的情况下发生分离，并且通常比大多数手性固定相更快且更有效。G-TA 也被用于分离母体药物对映体及其代谢物。G-TA 对含氧分析物的选择性最高，如醇、二醇和多元醇，作为游离醇和酰基衍生物；胺类作为酰基衍生物；氨基醇、卤素（Cl> Br> F）、氨基酸、羟基酸、内酯、呋喃和吡喃。它对卤化物也具有高选择性。
Application
Astec® CHIRALDEX™ G-TA（2，6-二-O-戊基-3-三氟乙酰基-γ-环糊精）衍生的环糊精手性固定相可用于毛细管气相色谱，用于从 7 种外消旋亚磺酸酯中分离四种异构体。将其用于通过分析海洋细菌 Erythrobacter litoralis HTCC2594 的开放阅读框（ORF）鉴定的三种环氧化物水解酶的克隆和表征的实验研究。它还用于 HPLC 和 GC 分析环氧化物的转化过程中，环氧化物水解酶从农杆菌放射杆菌（EchA）的对映选择性（使用易错 PCR 和 DNA 改组）。
Features and Benefits
温度限制：
- -10 °C 至 180 °C 等温和程序的
Other Notes
我们提供各种色谱配件，包括分析注射器
Legal Information
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIRALDEX is a trademark of Sigma-Aldrich Co. LLC
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商品
Chromatographic enantiomeric separation of amino acids, like proline, is described for chiral GC analysis after derivatization.
Jung-Hee Woo et al.
Applied microbiology and biotechnology, 76(2), 365-375 (2007-06-02)
Previously, we reported that ten strains belonging to Erythrobacter showed epoxide hydrolase (EHase) activities toward various epoxide substrates. Three genes encoding putative EHases were identified by analyzing open reading frames of Erythrobacter litoralis HTCC2594. Despite low similarities to reported EHases
Bert van Loo et al.
Chemistry & biology, 11(7), 981-990 (2004-07-24)
The enantioselectivity of epoxide hydrolase from Agrobacterium radiobacter (EchA) was improved using error-prone PCR and DNA shuffling. An agar plate assay was used to screen the mutant libraries for activity. Screening for improved enantioselectivity was subsequently done by spectrophotometric progress
Kinetic resolutions concentrate the minor enantiomer and aid measurement of high enantiomeric purity.
Caron, Gaetan; Tseng, George W.M.; Kazlauskas, R.J.
Tetrahedron Asymmetry, 5 (1), 83-92 (1994)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 73033AST | 04061832865065 |