Merck
CN

Y0002071

亚叶酸钙

European Pharmacopoeia (EP) Reference Standard

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别名:
亚叶酸 钙盐 水合物, 5-HCO-H4PteGlu, 5-甲酰基-5,6,7,8-四氢叶酸 钙盐, 5-甲酰基-5,6,7,8-四氢蝶酰基-L-谷氨酸 钙盐, 叶醛酸钙, 嗜橙菌因子 钙盐, 甲酰四氢叶酸 钙盐
Empirical Formula (Hill Notation):
C20H21CaN7O7 · xH2O
CAS号:
分子量:
511.50 (anhydrous basis)
Beilstein:
5723924

生物来源

synthetic

等级

pharmaceutical primary standard

Agency

EP

API family

folic acid

形式

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

−20°C

SMILES string

[Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13

InChI

1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1

InChI key

KVUAALJSMIVURS-ZEDZUCNESA-L

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此商品
F7878135800447612
Calcium folinate for system suitability European Pharmacopoeia (EP) Reference Standard

Y0002071

亚叶酸钙

-
Folinic acid calcium salt hydrate analytical standard

Supelco

F7878

亚叶酸 钙盐 水合物

-
USP

USP

1358004

亚叶酸 钙盐

-
Folinic acid calcium salt hydrate BioXtra, ≥99.0% (HPLC)

Sigma-Aldrich

47612

亚叶酸 钙盐 水合物

Premium Grade
format

neat

format

neat

format

neat

format

-

biological source

synthetic

biological source

synthetic (organic)

biological source

-

biological source

synthetic

agency

EP

agency

-

agency

-

agency

-

API family

folic acid

API family

-

API family

leucovorin

API family

-

form

solid

form

-

form

-

form

powder or crystals

一般描述

Calcium folinate, the reduced form of folic acid, finds application in the treatment of methotrexate overdose and in high-dose methotrexate chemotherapy as a chemotherapy protective drug to bring down the latter′s toxicity. When combined with fluorouracil, it is reported to be effective in the management of bowel cancer wherein it acts by inhibiting thymidylate synthase and augmenting the effect of fluorouracil.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Calcium folinate for system suitability may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.
叶酸拮抗剂通过结合二氢叶酸还原酶并阻滞叶酸转化为四氢叶酸盐发挥作用,而亚叶酸钙则可抵消叶酸拮抗剂的作用。在医学上,亚叶酸钙在甲氨蝶呤治疗后用于降低甲氨蝶呤的毒性。亚叶酸钙还可用于增强癌症治疗中 5-氟尿嘧啶的细胞毒性效应。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

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说明
价格

象形图

Exclamation markHealth hazard

警示用语:

Danger

危险分类

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Clinical Pharmacy Pocket Companion, 2nd edition
Clinical Pharmacy (2015)
Calcium folinate hydrate
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 6579-6581 (2019)

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