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Merck
CN

1370101

USP

洛匹那韦

United States Pharmacopeia (USP) Reference Standard

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关于此项目

经验公式（希尔记法）:
C37H48N4O5
化学文摘社编号:
192725-17-0
分子量:
628.80
MDL number:
MFCD22628840
UNSPSC Code:
41116107
NACRES:
NA.24

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产品名称

洛匹那韦, United States Pharmacopeia (USP) Reference Standard

SMILES string

N4(CCCNC4=O)[C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@@H](NC(=O)COc3c(cccc3C)C)Cc2ccccc2)Cc1ccccc1

InChI

1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1

InChI key

KJHKTHWMRKYKJE-SUGCFTRWSA-N

biological source

synthetic

grade

pharmaceutical primary standard

agency

USP/NF

API family

lopinavir

form

powder

packaging

pkg of 350 mg

manufacturer/tradename

USP

storage condition

protect from light

color

white to off-white

mp

255.2-260.6 °F (124—127°C)

solubility

chloroform: soluble
isopropanol: soluble
methanol: freely soluble
methylene chloride: freely soluble
water: practically insoluble

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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相关类别

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Lopinavir may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and plasma samples by chromatography techniques.

General description

Lopinavir is an antiretroviral agent and a protease inhibitor indicated for the management of human immunodeficiency virus (HIV) infection. It is a key component of Kaletra, the co-formulation of lopinavir and ritonavir.

Other Notes

Sales restrictions may apply.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Lopinavir USP Monograph
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 37(6), 2610-2610 (2020)
Simultaneous determination of indinavir, ritonavir and lopinavir (ABT 378) in human plasma by high-performance liquid chromatography
Ray J, et al.
Journal of Chromatography. B, Biomedical Applications, 775(2), 225-230 (2002)
Determination of 19 antiretroviral agents in pharmaceuticals or suspected products with two methods using high-performance liquid chromatography
Rebiere H, et al.
Journal of Chromatography. B, Biomedical Applications, 850(1-2), 376-383 (2007)
Therapeutic drug monitoring of lopinavir/ritonavir in pregnancy
Lambert JS, et al.
HIV Medicine, 12(3), 166-173 (2011)
Validation and application of a high-performance liquid chromatography-tandem mass spectrometric method for simultaneous quantification of lopinavir and ritonavir in human plasma using semi-automated 96-well liquid-liquid extraction
Wang PG, et al.
Journal of Chromatography A, 1130(2), 302-307 (2006)

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