1420006
USP
Levodopa Related Compound B
United States Pharmacopeia (USP) Reference Standard
别名:
DL-3-O-Methyldopa, 3-Methoxytyrosine
等级
pharmaceutical primary standard
API类
levodopa
制造商/商品名称
USP
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
NC(Cc1cc(c(cc1)O)OC)C(=O)O
InChI
1S/C10H13NO4/c1-15-9-5-6(2-3-8(9)12)4-7(11)10(13)14/h2-3,5,7,12H,4,11H2,1H3,(H,13,14)
InChI key
PFDUUKDQEHURQC-UHFFFAOYSA-N
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Levodopa Related Compound B USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:
Also, for use with USP monographs such as:
- Carbidopa and Levodopa Orally Disintegrating Tablets
- Levodopa
- Carbidopa and Levodopa Tablets
- Carbidopa and Levodopa Extended-Release Tablets
分析说明
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
其他说明
Sales restrictions may apply.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Li-Hsuan Wang et al.
Phytotherapy research : PTR, 24(6), 852-858 (2009-11-27)
The impacts of caffeic acid (3,4-dihydroxycinnamic acid, CA) on the pharmacokinetics of levodopa (L-dopa) were studied in rabbits. A single dose of 5/1.25 mg kg(-1) L-dopa/carbidopa was administered alone or was co-administered with three different doses of caffeic acid (2.5
Stephanie L Merhar et al.
Pediatrics, 116(5), 1226-1230 (2005-11-03)
Chronic bilirubin encephalopathy, characterized clinically by extrapyramidal movement abnormalities, vertical gaze abnormalities, and hearing loss, results from neuronal injury after marked hyperbilirubinemia in term and preterm infants. In premature infants, bilirubin staining of specific brain structures has been described at
Thomas Müller et al.
Naunyn-Schmiedeberg's archives of pharmacology, 383(6), 627-633 (2011-05-03)
Elevation of plasma total homocysteine concentrations were observed in levodopa/dopa decarboxylase inhibitor (DDI)-treated patients with Parkinson's disease (PD). Degradation of levodopa to 3-O-methyldopa via the enzyme catechol-O-methyltransferase (COMT) is a methyl group demanding reaction. It generates homocysteine from the methyl
T Müller et al.
Journal of neural transmission (Vienna, Austria : 1996), 114(11), 1457-1462 (2007-06-15)
The interval of line tracing performance is more associated to basal ganglia function due to the dependence on bradykinesia and rigidity. The other component of this task, the precision of execution of complex movement sequences, is more related to attention.
Yoritaka Onzawa et al.
Biological & pharmaceutical bulletin, 35(8), 1244-1248 (2012-08-07)
It has been well known that 3-O-methyldopa (3-OMD) is a metabolite of L-3,4-dihydroxyphenylalanine (L-DOPA) formed by catechol O-methyltransferase (COMT), and 3-OMD blood level often reaches higher than physiological level in Parkinson's disease (PD) patients receiving long term L-DOPA therapy. However
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