登录 查看组织和合同定价。
选择尺寸
关于此项目
线性分子式:
(CH3O)2C6H3CH2CH2N(CH3)(CH2)3C[C6H3(OCH3)2][CH(CH3)2]CN · HCl
化学文摘社编号:
分子量:
491.06
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
205-800-5
Beilstein/REAXYS Number:
3647093
MDL number:
产品名称
维拉帕米 盐酸盐, United States Pharmacopeia (USP) Reference Standard
InChI
1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
InChI key
DOQPXTMNIUCOSY-UHFFFAOYSA-N
SMILES string
Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
grade
pharmaceutical primary standard
API family
verapamil
manufacturer/tradename
USP
mp
142 °C (dec.) (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
Gene Information
human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)
正在寻找类似产品? 访问 产品对比指南
Analysis Note
这些产品仅供测试和分析使用。它们不适用于人类或动物的给药，不可用于诊断、治疗或治愈任何疾病。
Application
盐酸维拉帕米USP参考标准品的预期用途是USP规定的指定质量测试和检测。也用于USP各论，例如：
- 盐酸维拉帕米注射液
- 盐酸维拉帕米片
- 盐酸维拉帕米胶囊
- 盐酸维拉帕米缓释片
- 盐酸维拉帕米复方口服液
- 盐酸维拉帕米复方口服混悬液
Biochem/physiol Actions
α1-肾上腺素受体拮抗剂；L型钙通道阻滞剂。
α1-肾上腺素受体拮抗剂；L型钙通道阻滞剂。阻断平滑肌和心肌中的 L 型 Ca2+ 通道，体外诱导人原发性和转移性结肠癌细胞的凋亡。对 PGP 起作用的抗药性逆转剂，如减少肾小管清除地高辛。增加 Pgp 的基础 ATP 酶活性。Cyp3A4 和 CYP2C6 的底物。
General description
本产品按照现行药典要求提供和指定。所有为支持本产品而提供的信息，包括 SDS 和任何产品信息小册子，均由药典颁发机构制定和发布。如需进一步信息和支持，请访问现行药典网站。
Other Notes
可能适用相应的销售限制。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
S H Baky et al.
Pharmacotherapy, 2(6), 328-353 (1982-11-01)
Verapamil hydrochloride, a prototype calcium antagonist, is now marketed in the United States for the acute treatment of supraventricular tachyarrhythmias and for chronic management of vasospastic and chronic stable angina. It inhibits the slow inward channel in in the heart
Acute respiratory distress syndrome after verapamil intoxication: case report and literature review.
S Izdes et al.
Acta clinica Belgica, 69(2), 116-119 (2014-04-15)
Verapamil intoxication is a life-threatening condition that often presents with severe hemodynamic instability and requires vasopressor support. There are also documented case reports of the development of non-cardiogenic pulmonary oedema after verapamil overdose. However, the exact mechanisms responsible for pulmonary
Soon Hyung Park et al.
The Laryngoscope, 124(6), 1444-1451 (2013-10-25)
We investigated whether the round window membrane (RWM) vibration can facilitate dexamethasone perfusion via the RWM in patients with sudden hearing loss. Prospective study. We first performed an in vitro study using a semipermeable membrane. In the subsequent in vivo
Anurag Pandey et al.
The Journal of physiology, 592(16), 3537-3557 (2014-06-08)
The subiculum is a structure that forms a bridge between the hippocampus and the entorhinal cortex (EC), and plays a major role in the memory consolidation process. Here, we demonstrate spike-timing-dependent plasticity (STDP) at the proximal excitatory inputs on the
Yasuo Uchida et al.
The Journal of pharmacology and experimental therapeutics, 350(3), 578-588 (2014-06-21)
The aim of this study was to investigate whether in vivo drug distribution in brain in monkeys can be reconstructed by integrating four factors: protein expression levels of P-glycoprotein (P-gp)/multidrug resistance protein 1 at the blood-brain barrier (BBB), in vitro
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持