V900396
组胺
Vetec™, reagent grade, ≥97%
别名:
2-(4-咪唑基)乙胺
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关于此项目
经验公式（希尔记法）:
C5H9N3
化学文摘社编号:
分子量:
111.15
EC Number:
200-100-6
UNSPSC Code:
12352116
PubChem Substance ID:
Beilstein/REAXYS Number:
2012
MDL number:
产品名称
组胺, Vetec™, reagent grade, ≥97%
InChI key
NTYJJOPFIAHURM-UHFFFAOYSA-N
InChI
1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
SMILES string
NCCc1c[nH]cn1
grade
reagent grade
product line
Vetec™
assay
≥97%
bp
167 °C/0.8 mmHg (lit.)
mp
83-84 °C (lit.)
storage temp.
−20°C
Gene Information
human ... HRH1(3269)
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Biochem/physiol Actions
内源性 H1 和 H2 组胺受体激动剂；H1 的活化可以使 Ca2+ 移动；H2 的活化可促进神经元中腺苷酸环化酶的活性；活化一氧化氮合成酶；有效的血管舒张剂。
内源性 H1 和 H2 组胺受体激动剂；可活化一氧化氮合成酶；有效的血管舒张剂。
Legal Information
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
David P Roberson et al.
Nature neuroscience, 16(7), 910-918 (2013-05-21)
The peripheral terminals of primary sensory neurons detect histamine and non-histamine itch-provoking ligands through molecularly distinct transduction mechanisms. It remains unclear, however, whether these distinct pruritogens activate the same or different afferent fibers. Using a strategy of reversibly silencing specific
Marieke Smit et al.
The Journal of pharmacology and experimental therapeutics, 348(2), 303-310 (2013-12-07)
The novel once-daily β₂-agonist bronchodilator drug olodaterol has recently been shown to be effective in patients with allergic asthma for >24 hours. An increased cholinergic tone common to these patients may decrease the effectiveness of β₂-agonists. This could provide a
Pertti Panula et al.
Nature reviews. Neuroscience, 14(7), 472-487 (2013-06-21)
Histamine acts as a modulatory neurotransmitter in the mammalian brain. It has an important role in the maintenance of wakefulness, and dysfunction in the histaminergic system has been linked to narcolepsy. Recent evidence suggests that aberrant histamine signalling in the
Lena Böhn et al.
The American journal of gastroenterology, 108(5), 634-641 (2013-05-07)
Despite the fact that food and diet are central issues, that concern patients with irritable bowel syndrome (IBS), the current understanding about the association between the intake of certain foods/food groups and the gastrointestinal (GI) symptom pattern, psychological symptoms, and
Franziska Glatzer et al.
The Journal of allergy and clinical immunology, 132(6), 1358-1367 (2013-08-13)
Epidermal hyperproliferation resulting in acanthosis is an important clinical observation in patients with atopic dermatitis, and its underlying mechanisms are not completely understood. Because increased levels of histamine are present in lesional skin, we investigated the effect of histamine, especially
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