Merck
CN
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文件

V900931

Sigma-Aldrich

曲古抑菌素A 

Vetec™, reagent grade, from Streptomyces sp., ≥98%

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别名:
曲古抑菌素A, TSA, [R-(E,E)]-7-[4-（二甲氨基）苯基]-N-羟基-4,6-二甲基-7-氧代-2,4-庚二烯酰胺
经验公式（希尔记法）:
C17H22N2O3
CAS号:
58880-19-6
分子量:
302.37
MDL编号:
MFCD03848392
PubChem化学物质编号:
329830233

生物来源

Streptomyces sp.

等级

reagent grade

产品线

Vetec™

检测方案

≥98%

储存温度

−20°C

SMILES字符串

C[C@H](\C=C(C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C

InChI

1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1

InChI key

RTKIYFITIVXBLE-QEQCGCAPSA-N

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生化/生理作用

抑制纳摩浓度的组蛋白脱乙酰基酶；组蛋白高乙酰化生成物会导致染色质弛豫并调节基因表达。可能参与多种细胞类型细胞周期过程，诱导G和G/M期细胞生长停滞；可能诱导细胞凋亡。增强靶向DNA的抗癌症剂的效力。

法律信息

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

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