- Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors.
Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors.
Bioorganic & medicinal chemistry (2009-10-06)
Hee-Kyung Rhee, So Yun Lim, Mi-Ja Jung, Youngjoo Kwon, Myung-Hwa Kim, Hea-Young Park Choo
PMID19800803
摘要
The isoquinolinone-based tetracyclic compounds were designed and synthesized and their PARP-1 inhibitory activity was evaluated. Most of synthesized compounds showed fairly good activity. Also the most active compound 6 showed its activity on potentiation of anticancer agents, temozolamide and etoposide, by 1.7 times, respectively.