CN
CDK6
cyclin-dependent kinase 6
别名:
PLSTIRE
物种:
Human CDK6 (1021), Mouse Cdk6 (12571), Rat Cdk6 (114483), domestic guinea pig Cdk6 (100732773), naked mole-rat Cdk6 (101719908), Domestic Rabbit CDK6 (100009040), sheep CDK6 (100144761), Horse CDK6 (100061625), cow CDK6 (511754), dog CDK6 (609920) ...展开
UniProtKB ID:
基因ID:
- Human(1021) Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
- Mouse(12571) cyclin-dependent kinase 6
- Rat(114483) cyclin-dependent kinase 6
- domestic guinea pig(100732773) cyclin-dependent kinase 6
- naked mole-rat(101719908) cyclin-dependent kinase 6
- Domestic Rabbit(100009040) cyclin-dependent kinase 6
- sheep(100144761) cyclin-dependent kinase 6
- Horse(100061625) cyclin-dependent kinase 6
- cow(511754) cyclin-dependent kinase 6
- dog(609920) cyclin-dependent kinase 6
- domestic cat(100037415) cyclin-dependent kinase 6
- chicken(420558) cyclin-dependent kinase 6
- Zebrafish(100034507) cyclin-dependent kinase 6
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Antibodies
货号
说明
物种反应性
应用
抗-CDK6 兔抗, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-CDK6 Antibody, clone 2J3 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human, mouse, rat
应用
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Monoclonal Anti-CDK6 antibody produced in mouse, clone 8H4, purified immunoglobulin, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence
immunohistochemistry
proximity ligation assay
western blot
immunofluorescence
immunohistochemistry
proximity ligation assay
western blot
Anti-CDK6 (Ab-24) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
immunohistochemistry
western blot
western blot
Anti-CDK6 antibody produced in rabbit, ,
物种反应性
human, mouse
应用
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Small Molecule - Inhibitor
Proteins
货号
说明
物种
Cdk6/Cyclin D3 Protein, active, 10 µg, Active, N-terminal, His6-tagged full length human Cdk6 complexed with N-terminal GST-tagged full-length human Cyclin D3, for use in Kinase Assays.,
物种
human
CDK6/CyclinD1, active, His/GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human