Merck
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GABRA4

gamma-aminobutyric acid (GABA) A receptor, alpha 4

别名:
物种:
UniProtKB ID:
基因ID:
  • Human(2557) Summary: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011]
  • Mouse(14397) gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
  • Rat(140675) gamma-aminobutyric acid (GABA) A receptor, alpha 4
  • chicken(422770) gamma-aminobutyric acid (GABA) A receptor, alpha 4
  • cow(282238) gamma-aminobutyric acid (GABA) A receptor, alpha 4
  • dog(482132) gamma-aminobutyric acid (GABA) A receptor, alpha 4
  • sheep(101121776) gamma-aminobutyric acid (GABA) A receptor, alpha 4
  • domestic cat(101098052) gamma-aminobutyric acid (GABA) A receptor, alpha 4
  • domestic guinea pig(100721252) gamma-aminobutyric acid (GABA) A receptor, alpha 4
  • naked mole-rat(101718327) gamma-aminobutyric acid (GABA) A receptor, alpha 4
  • Domestic Rabbit(100339882) gamma-aminobutyric acid (GABA) A receptor, alpha 4

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Small Molecule - Agonist

货号
说明
物种
蝇蕈醇 氢溴酸盐, ≥98% (HPLC), solid,
物种
human
Piperidine-4-sulfonic acid, ,
物种
human
加波沙朵 盐酸盐, solid, ≥98% (HPLC),
物种
human
γ-氨基丁酸, ≥99%,
物种
human, rat
2-溴-2-氯-1,1,1-三氟乙烷, ≥99%,
物种
human

Small Molecule - Allosteric Modulator

货号
说明
物种
丙泊酚标准液 CRM 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
物种
human
司可巴比妥 钠盐, ,
物种
human
普鲁泊福, European Pharmacopoeia (EP) Reference Standard,
物种
human
Prazepam, European Pharmacopoeia (EP) Reference Standard,
物种
human
丙泊酚, 97%,
物种
human

Small Molecule - Antagonist

货号
说明
物种
SR-95531, ≥98% (HPLC), powder,
物种
human
Flumazenil, United States Pharmacopeia (USP) Reference Standard,
物种
human
丙泊酚, 97%,
物种
human
Ganaxolone, solid, ≥98% (HPLC),
物种
human, mouse
阿坎酸钙, ≥98% (HPLC), powder,
物种
human

Antibodies

货号
说明
物种反应性
应用
Monoclonal Anti-GABA A Receptor-PerCP antibody produced in mouse, clone S398A-34,
物种反应性
human, mouse
应用
immunofluorescence
western blot
Monoclonal Anti-GABA A Receptor-Biotin antibody produced in mouse, clone S398A-34,
物种反应性
human, mouse
应用
immunofluorescence
western blot
Anti-GABA A Receptor α4 Antibody, CT, Chemicon®, from rabbit,
物种反应性
human, mouse, rat
应用
immunoprecipitation (IP)
western blot
Anti-GABRA4 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
物种反应性
bovine, human
应用
ELISA
immunohistochemistry

western blot
Monoclonal Anti-GABA A Receptor-Atto 390 antibody produced in mouse, clone S398A-34,
物种反应性
human, mouse
应用
immunofluorescence
western blot

Small Molecule - Inhibitor

货号
说明
物种
(±)-Vigabatrin, ,
物种
human
NO-711 hydrochloride, ≥98% (HPLC),
物种
human
丙泊酚, 97%,
物种
human
托吡酯, Pharmaceutical Secondary Standard; Certified Reference Material,
物种
human
托吡酯, United States Pharmacopeia (USP) Reference Standard,
物种
human

Small Molecule - Ligand

货号
说明
物种
2-溴-2-氯-1,1,1-三氟乙烷, ≥99%,
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human GABRA4,
物种
human
MISSION® esiRNA, targeting mouse Gabra4,
物种
mouse