Merck
CN

PPM1A

protein phosphatase, Mg2+/Mn2+ dependent, 1A

别名:
PP2C-ALPHA, PP2CA, PP2Calpha
物种:
UniProtKB ID:
基因ID:
  • Human(5494) Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
  • Mouse(19042) protein phosphatase 1A, magnesium dependent, alpha isoform
  • Rat(24666) protein phosphatase, Mg2+/Mn2+ dependent, 1A
  • Domestic Rabbit(100009431) protein phosphatase, Mg2+/Mn2+ dependent, 1A
  • domestic cat(101101571) protein phosphatase, Mg2+/Mn2+ dependent, 1A
  • naked mole-rat(101720711) protein phosphatase, Mg2+/Mn2+ dependent, 1A
  • sheep(101103650) protein phosphatase, Mg2+/Mn2+ dependent, 1A
  • domestic guinea pig(100734826) protein phosphatase, Mg2+/Mn2+ dependent, 1A
  • cow(281994) protein phosphatase, Mg2+/Mn2+ dependent, 1A
  • dog(480344) protein phosphatase, Mg2+/Mn2+ dependent, 1A
  • chicken(423525) protein phosphatase, Mg2+/Mn2+ dependent, 1A

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Antibodies

货号
说明
物种反应性
应用
Anti-PPM1A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry

western blot
Anti-PPM1A, clone 7F12 Antibody, clone 7F12, from mouse,
物种反应性
human
应用
ELISA
flow cytometry

western blot
Anti-PPM1A antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
immunofluorescence
western blot

Small Molecule - Inhibitor

货号
说明
物种
六亚甲基二胺, 98%,
物种
rat
精脒, BioReagent, for molecular biology, suitable for cell culture, ≥98%,
物种
rat
精脒, ≥99% (GC),
物种
rat
精脒, BioUltra, for molecular biology, ≥99.5% (GC),
物种
rat
牛磺酸, suitable for cell culture, meets USP testing specifications,
物种
rat

Proteins

货号
说明
物种
PP2C α 人, recombinant, expressed in E. coli, ≥95% (SDS-PAGE),
物种
human
PP2C-α, active, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human PPM1A,
物种
human
MISSION® esiRNA, targeting mouse Ppm1a,
物种
mouse