ADD3
adducin 3 (gamma)
别名:
ADDL
物种:
Human ADD3 (120), Mouse Add3 (27360), Rat Add3 (25230), chicken ADD3 (373892), dog ADD3 (486881), domestic cat ADD3 (101091902), Horse ADD3 (100059447), cow ADD3 (505225), sheep ADD3 (101117808), domestic guinea pig Add3 (100735302)
UniProtKB ID:
基因ID:
- Human(120) Summary: Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]
- Mouse(27360) adducin 3 (gamma)
- Rat(25230) adducin 3 (gamma)
- chicken(373892) adducin 3 (gamma)
- dog(486881) adducin 3 (gamma)
- domestic cat(101091902) adducin 3 (gamma)
- Horse(100059447) adducin 3 (gamma)
- cow(505225) adducin 3 (gamma)
- sheep(101117808) adducin 3 (gamma)
- domestic guinea pig(100735302) adducin 3 (gamma)
- naked mole-rat(101715401) adducin 3 (gamma)
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Antibodies
产品编号
说明
物种反应性
应用
抗-ADD3 兔抗, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-ADD3 antibody produced in rabbit, affinity isolated antibody,
物种反应性
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
应用
ELISA
western blot
western blot