CN
ALOX5
arachidonate 5-lipoxygenase
Synonyms:
5-LO, 5-LOX, 5LPG, LOG5
Species:
Human ALOX5 (240), Mouse Alox5 (11689), Rat Alox5 (25290), sheep ALOX5 (101117390), naked mole-rat Alox5 (101700210), Zebrafish alox5 (573013), Zebrafish alox5 (567204), chicken ALOX5 (423769), dog ALOX5 (477753), cow ALOX5 (404074) ...More
UniProtKB ID:
Gene ID:
- Human(240) Summary: This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
- Mouse(11689) arachidonate 5-lipoxygenase
- Rat(25290) arachidonate 5-lipoxygenase
- sheep(101117390) arachidonate 5-lipoxygenase
- naked mole-rat(101700210) arachidonate 5-lipoxygenase
- Zebrafish(573013) arachidonate 5-lipoxygenase
- Zebrafish(567204) arachidonate 5-lipoxygenase
- chicken(423769) arachidonate 5-lipoxygenase
- dog(477753) arachidonate 5-lipoxygenase
- cow(404074) arachidonate 5-lipoxygenase
- domestic cat(101097422) arachidonate 5-lipoxygenase
- Horse(100062042) arachidonate 5-lipoxygenase
- domestic guinea pig(100718093) arachidonate 5-lipoxygenase
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-ALOX5 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse
Application
immunofluorescence
western blot
western blot
Anti-Arachidonate 5 Lipoxygenase antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Phospho-ALOX5-S271 antibody produced in rabbit, ,
Species Reactivity
human
Application
western blot
Anti-ALOX5 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-5′-Lipoxygenase Antibody, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rabbit, rat
Application
ELISA
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot