CN
HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase
Synonyms:
LDLCQ3
Species:
Human HMGCR (3156), Mouse Hmgcr (15357), Rat Hmgcr (25675), chicken HMGCR (395145), fruit fly Hmgcr (42803), sheep HMGCR (101108919), naked mole-rat Hmgcr (101717005), domestic guinea pig Hmgcr (100726509), cow HMGCR (407159), Horse HMGCR (100065577) ...More
UniProtKB ID:
Gene ID:
- Human(3156) Summary: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
- Mouse(15357) 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
- Rat(25675) 3-hydroxy-3-methylglutaryl-CoA reductase
- chicken(395145) 3-hydroxy-3-methylglutaryl-CoA reductase
- fruit fly(42803) HMG Coenzyme A reductase
- sheep(101108919) 3-hydroxy-3-methylglutaryl-CoA reductase
- naked mole-rat(101717005) 3-hydroxy-3-methylglutaryl-CoA reductase
- domestic guinea pig(100726509) 3-hydroxy-3-methylglutaryl-CoA reductase
- cow(407159) 3-hydroxy-3-methylglutaryl-CoA reductase
- Horse(100065577) 3-hydroxy-3-methylglutaryl-CoA reductase
- domestic cat(101098922) 3-hydroxy-3-methylglutaryl-CoA reductase
- dog(479182) 3-hydroxy-3-methylglutaryl-CoA reductase
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Activity Assay
Product Number
Description
Species
HMG-CoA Reductase Assay Kit, sufficient for 30 assays (1 mL), sufficient for 100 assays (200 μL),
Species
human
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-HMG-CoA reductase Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human, primate
Application
immunoprecipitation (IP)
western blot
western blot
Anti-HMGCR (internal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-HMG-CoA Reductase Antibody, clone IgG-A9, clone IgG-A9, from mouse,
Species Reactivity
hamster, human, rat
Application
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-HMGCR antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-HMGCR antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Simvastatin for system suitability CRS, European Pharmacopoeia (EP) Reference Standard,
Species
human
Proteins
Product Number
Description
Species