CN
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Synonyms:
GCCR, GCR, GR, GRL
Species:
Human NR3C1 (2908), Mouse Nr3c1 (14815), Rat Nr3c1 (24413), domestic guinea pig Nr3c1 (100135583), cow NR3C1 (281946), Domestic Rabbit NR3C1 (100008890), Horse NR3C1 (100061217), Zebrafish nr3c1 (553740), sheep NR3C1 (443412), dog NR3C1 (478047) ...More
UniProtKB ID:
Gene ID:
- Human(2908) Summary: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
- Mouse(14815) nuclear receptor subfamily 3, group C, member 1
- Rat(24413) nuclear receptor subfamily 3, group C, member 1
- domestic guinea pig(100135583) nuclear receptor subfamily 3, group C, member 1
- cow(281946) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- Domestic Rabbit(100008890) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- Horse(100061217) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- Zebrafish(553740) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- sheep(443412) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- dog(478047) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- chicken(416343) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- domestic cat(101080939) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- domestic cat(692348) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- naked mole-rat(101722101) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
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Small Molecule - Activator
Small Molecule - Agonist
Product Number
Description
Species
Cortisol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Dexamethasone solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Prednisolone solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Prednisone solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Small Molecule - Antagonist
Product Number
Description
Species
Testosterone solution, 1.0 mg/mL in 1,2-dimethoxyethane, drug standard,
Species
mouse, human, rat
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-NR3C1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Anti-phospho Glucocorticoid Receptor (Ser134) Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
canine, feline, horse, human, rat, sheep
Application
western blot
Anti-Glucocorticoid Receptor (Ab-2) Mouse mAb (BuGR2), lyophilized, clone BuGR2, Calbiochem®,
Species Reactivity
guinea pig, mouse, rabbit, rat, sheep
Application
Anti-Glucocorticoid Receptor Antibody, serum, from rabbit,
Species Reactivity
bovine, canine, feline, horse, human, mouse, nonhuman primates
Application
affinity binding assay
western blot
western blot
Anti-Phospho-NR3C1-S211 antibody produced in rabbit, ,
Species Reactivity
human
Application
western blot