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Merck
CN

NXF-10

Millipore

Natrix® Q 小试装置

Natrix® Q Pilot (15 mL), pack of 1 device

别名:

Natrix® Q膜吸附器

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UNSPSC代码:
41115711
eCl@ss:
32011308

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产品名称

Natrix® Q 小试装置,

ligand

quaternary amine

质量水平

400

描述

Natrix® Q Pilot

产品线

Natrix®

参数

75-375 mL/min flow rate

床高度

0.5 mm

柱床体积

15 mL

基质活性基团

Macroporous polymer

孔径

0.4 μm pore size

容量

3 g binding capacity (BSA)(per device)

分离技术

strong anion exchange

运输

ambient

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相关类别

一般描述

Natrix®(Q)层析膜采用革命性的三维大孔水凝胶结构，提供了高密度的吸附位点和快速传质，其吸附能力超过了树脂填料柱，兼具传统膜吸附剂常见的高流速。性能和速度兼备，搭配一次性、即插即用设计为生物分子纯化提供了低风险、可放大的高效解决方案。

Natrix®(Q)层析膜是一种高生产率强阴离子交换膜，专为生物分子纯化而设计。该独特的 Natrix® Q层析膜是一种多孔聚丙烯酰胺水凝胶，含有高密度的季铵 (Q) 结合基团，这些基团直接聚合在惰性大孔膜支架内。互连的孔隙结构和高官能团密度可实现快流速（几秒的停留时间），并在极高负载下具有出色的通量，同时在各种缓冲条件下保持优异的杂质减少率。Natrix®(Q)层析膜设计可提高任何生物工艺设计的生产率、灵活性、工艺稳健性和经济性。Natrix®(Q) Pilot是中等规模的层析膜装置，用于验证和调整操作参数。可用于小规模的临床和商业化生产。
标称单抗精纯能力：150 g

膜结构：有褶的

每个包装 1 台设备
强阴离子交换层析膜设计，可纯化具有高密度季胺配体的生物分子，可在高负载下实现快流速和高通量，同时保持优异的杂质减少率

特点和优势

Natrix® Q 膜吸附器为用户提供：

  • 高密度季胺结合位点可实现快速传质
  • 即使在快流速下也具有高结合能力
  • 一次性、即插即用设备格式的性能和速度相结合，可实现低风险、可扩展的高效生物分子纯化解决方案。

包装

双袋装

法律信息

NATRIFLO is a trademark of Merck KGaA, Darmstadt, Germany
NATRIX is a registered trademark of Merck KGaA, Darmstadt, Germany

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Mochao Zhao et al.
Vaccine, 37(36), 5491-5503 (2018-04-09)
Affinity chromatography is among the most powerful separation techniques, achieving the finest separation with high yields even in the most challenging feed streams. Incorporating affinity chromatography in vaccine purification has long been attempted by researchers to improve unit yield and
Renaud Jacquemart et al.
Computational and structural biotechnology journal, 14, 309-318 (2016-08-30)
The current processing paradigm of large manufacturing facilities dedicated to single product production is no longer an effective approach for best manufacturing practices. Increasing competition for new indications and the launch of biosimilars for the monoclonal antibody market have put
Ying Hou et al.
Biotechnology progress, 31(4), 974-982 (2015-05-29)
Protein A chromatography is widely employed for the capture and purification of monoclonal antibodies (mAbs). Because of the high cost of protein A resins, there is a significant economic driving force to seek new downstream processing strategies. Membrane chromatography has

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